Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Leyva-Ramos, Socorro, once mentioned the application of 620-92-8, Name is 4,4′-Methylenediphenol, molecular formula is C13H12O2, molecular weight is 200.23, MDL number is MFCD00002385, category is naphthyridines. Now introduce a scientific discovery about this category, Recommanded Product: 4,4′-Methylenediphenol.
Microwave-assisted synthesis of ethyl 7-chloro-4-oxo-l,4-dihydro-1,8-naphthyridine-3-carboxylate by the Grohe-Heitzer reaction
A simple and efficient two-step method was implemented for the synthesis of ethyl 7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate. Comparing with the reported Grohe-Heitzer reaction, the time and the reaction steps have been reduced using microwave irradiation. This compound is an important intermediate for the preparation of naphthyridone derivatives which have received significant attention due to their broad spectrum of biological activity.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem