Let¡¯s face it, organic chemistry can seem difficult to learn, Quality Control of Tetrazolium Red, Especially from a beginner¡¯s point of view. Like 298-96-4, Name is Tetrazolium Red, molecular formula is naphthyridines, belongs to naphthyridines compound. In a document, author is Chaitanya, M. V. S. R. K., introducing its new discovery.
SYNTHESIS OF NOVEL NAPTHTHYRIDINES AS POTENTIAL ANTIBACTERIAL AGENTS
The reaction of 2-aminopyridine (1) with ethoxymethylenemalonic ester gave 4-ethoxy-3-oxo-2-(pyridine-2-yl aminomethylene)-butyric acid ethyl ester (2) which on cyclization in the presence of hot PPA gave 4-oxo-1,4-dihydro-[1,8] naphthyridine-3-carboxylic acid ethyl ester (3). The latter on reaction with hydrazine hydrate resulted in, 4-oxo-1,4-dihydro-[1,8] naphthyridine-3-carboxylic acid hydrazide (4). The reaction of 4 in acetic acid with benzaldehydes yielded 3-(5-phenyl-[1,3,4] oxadiazol-2-yl)-1H-[1,8] naphthyridin-4-ones (5). In another reaction, 4 on treatment with acetylacetone gave 3-(3,5-dimethyl-pyrazole-1-carbonyl)-1H-[1,8] naphthyridin-4-ones (6). The hydrazide 4 was further cyclized with carbon disulphide in the presence of potassium hydroxide followed by acidification to get 3-(5-mercapto-[1,3,4] thiadiazol-2-yl)-1H-[1,8] naphthyridin-4-ones (7).
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem