Reference of 1118-61-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1118-61-2, Name is 3-Aminocrotononitrile, SMILES is CC(N)=CC#N, belongs to naphthyridines compound. In a article, author is Mishra, Brijeshkunvar J., introduce new discover of the category.
QSAR study of anticancer agents: 1,8-naphthyridine derivatives
In a persevering effort to develop better anticancer drugs, a quantitative structure-activity relationship analysis using a set of 2-D descriptors was performed on a series of 1,8-naphthyridine derivatives acting by the inhibition of tubulin polymerization. QSAR models that were derived from the study were found to be statistically significant with a good predicting ability. The results obtained from the study justify the use of 2-D descriptors for exploring the requirements of binding of 1,8-naphthyridines to the heterodimer, tubulin. An attempt has been made to explore the structural and/or physico-chemical requirements of the compounds, responsible for the action against turnout cells. The physico-chemical descriptors and indicator variables were correlated with the biological activity.
Reference of 1118-61-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1118-61-2.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem