Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.1118-61-2, Name is 3-Aminocrotononitrile, SMILES is CC(N)=CC#N, belongs to naphthyridines compound. In a document, author is Ye, Pengqing, introduce the new discover, Recommanded Product: 3-Aminocrotononitrile.
Rare-Earth-Metal-Catalyzed Synthesis of Azaindolines and Naphthyridines via C-H Cyclization of Functionalized Pyridines
We report herein a rare-earth-metal-catalyzed insertion of a 2-pyridine C(sp(2))-H bond into an intramolecular unactivated vinyl bond. This reaction provides streamlined access to a range of azaindolines in moderate to excellent yields. The salient features of this reaction include simple and mild reaction conditions, 100% atom efficiency, and wide substrate scope. This methodology is also used to construct other nitrogen-containing compounds such as naphthyridine derivatives. A plausible mechanism for the formation of azaindolines involving initial C-H bond activation by the lanthanide complex followed by C=C insertion into a Ln-C bond to form an alkyl lanthanide species that subsequently undergoes cyclization is proposed.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1118-61-2 is helpful to your research. Recommanded Product: 3-Aminocrotononitrile.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem