A new application about Trimethyl(vinyl)silane

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In an article, author is Melzer, Benedikt C., once mentioned the application of 754-05-2, Name is Trimethyl(vinyl)silane, molecular formula is C5H12Si, molecular weight is 100.2343, MDL number is MFCD00008606, category is naphthyridines. Now introduce a scientific discovery about this category, Recommanded Product: 754-05-2.

Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogues of pyridoacridine alkaloids

Readily available 4-bromobenzo[c][2,7]naphthyridine undergoes regioselective direct ring metalation at C-5 with TMPMgCl center dot LiCl at -40 degrees C. Quenching with various electrophiles gives a broad range of 5-substituted products, which are building blocks for the synthesis of heterocyclic natural products and analogues thereof. In combination with a Parham-type cyclization a novel approach to pyrido[4,3,2-mn]acridones has been worked out.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem