Chemistry, like all the natural sciences, Formula: 100.2343, begins with the direct observation of nature¡ª in this case, of matter.754-05-2, Name is Trimethyl(vinyl)silane, SMILES is C=C[Si](C)(C)C, belongs to naphthyridines compound. In a document, author is Goerlitzer, K., introduce the new discover.
Benzo[c][2,7]naphthyridine-5-yl-arylamines – phenol Mannich bases of the amodiaquine-, cycloquine- and pyronarldine-type
2,5-Dichloro-4-methyl-benzo[c][2,7]naphthyridine (1) reacted with aromatic amines selectively by substitution at the 5-position to yield the amidines 2. The 4-aminophenol 2c could also be synthesized by cleavage of the ether 2b. The structure of 2c was proved by X-ray crystal analysis. Aminomethylation of 2c yielded the amodiaquine analogue 3. The mono- and bisaminomethylated derivatives 4 and 5 were obtained by reaction of compound 1 with phenol Mannich base hydrochlorides. Compounds 3-5 were tested in vitro for antimalarial activity using chloroquine-sensitive and resistant Plasmodium-falciparum strains. The highest activities were shown by the pyronaridine-type compounds 5a and 5b with IC50 values of approximately 200 nM.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 754-05-2. Formula: 100.2343.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem