100361-18-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, cas is 100361-18-0,the naphthyridine compound, it is a common compound, a new synthetic route is introduced below.
Acetonitrile (1900ml), 3-aminomethyl-4-methoxyiminopyrrolidine dimethanesulfonate (248. Og) and water (100ml) were in turn introduced into a reaction vessel and cooled to 0- 5° C. Benzaldehyde (97.6g) and triethylamine (229. 1g) were in turn added to the reaction mixture. After stirring the mixture for 0. 5h, 7-chloro-1-cyclopropyl-6-fluoro-1, 4- dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid (200. 0g) was introduced thereto. The resultant reaction mixture was slowly heated to room temperature, while stirring it. Then, the reaction was carried out by stirring the reaction mixture for about 3h at room temperature. The reaction material, which was formed in the form of a dispersion solution upon producing the title compound, was filtered, washed with water and acetonitrile, and then dried to prepare 320.3 g of the title compound (Yield: 94. 8%).’H NMR (6, CDC13) : 8.66 (s, 1H), 8. 32 (s, 1H), 7. 98 (d, J=12. 4Hz, 1H), 7.60 (d, J=7. 0Hz, 2H), 7. 37 (t, J=7.4Hz, 1H), 7.31 (t, J=7.4Hz, 2H), 4. 58 (s, 2H), 4. 21-4. 15 (m, 2H), 4.00 (m, 1H), 3.93 (s, 3H), 3.83 (m, 1H), 3.56 (m, 1H), 3.40 (m, 1H), 1.21 (m, 2H), 1.00 (m, 2H) Mass (FAB): 478 (M+H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, 100361-18-0
Reference£º
Patent; LG LIFE SCIENCES LTD.; WO2003/87100; (2003); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem