With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.249889-68-7,8-Chloro-2-methoxy-1,5-naphthyridine,as a common compound, the synthetic route is as follows.
Under an atmosphere of argon, a mixture of 4-chloro-6-methoxy-l,5-naphthyridine (0.485 g), methyl 2-(5-hydroxy-3-methoxypyridin-2-yl)acetate (0.493 g), caesium carbonate (1.63 g) and DMF (10 ml) was stirred and heated to 13O0C for 7 hours. The resultant mixture was cooled to ambient temperature and partitioned between ethyl acetate and water. The organic phase was dried over magnesium sulphate and evaporated. The residue was purified by column chromatography on silica using increasingly polar mixtures of ethyl acetate and methanol as eluent. There was thus obtained methyl 2-[3-methoxy-5-(6-methoxy- l,5-naphthyridin-4-yloxy)pyridin-2-yl]acetate as a solid (0.51 g); 1H NMR Spectrum:
The synthetic route of 249889-68-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/113548; (2007); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem