100361-18-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, cas is 100361-18-0,the naphthyridine compound, it is a common compound, a new synthetic route is introduced below.
Acetonitrile (100ml), 3-aminomethyl-4-methoxyiminopyrrolidine dimethanesulfonate (12. 5g), 2-hydroxybenzaldehyde (8.6g) and triethylamine (12.2g) were in turn introduced into a reaction vessel at room temperature. After stirring the mixture for about 0. 5h, 7- chloro-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-1, 8- naphthyridine-3-carboxylic acid (lO. Og) was introduced thereto. The resultant reaction mixture was stirred for about 15h at room temperature, cooled to O~ 5 C, and stirred for about 3h. The title compound in the form of solid was filtered, washed with acetonitrile, and dried to prepare 16.0 g of the title compound (Yield: 91. 8%). ‘H NMR (6, CDC13) : 8. 68 (s, 1H), 8.42 (s, 1H), 8.01 (d, J=12.4Hz, 1H), 7. 30-7. 20 (m, 3H), 6. 90-6. 82 (m, 2H), 4. 68-4. 53 (m, 2H), 4. 32-4. 24 (m, 1H), 4.06 (dd, J1=11. 9Hz, J2=5. 5Hz, 1H), 4. 02-3. 85 (m, 3H), 3.95 (s, 3H), 3.60 (m, 1H), 3.40 (m, 1H), 1. 29-1. 21 (m, 2H), 1. 07-1. 00 (m, 2H) Mass (FAB): 494 (M+H)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, 100361-18-0
Reference£º
Patent; LG LIFE SCIENCES LTD.; WO2003/87100; (2003); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem