Electric Literature of 15944-34-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 15944-34-0, 7-Chloro-1,8-naphthyridin-2-ol, introducing its new discovery.
A new three-step procedure for pyridine annulation is described and illustrated with efficient syntheses of various 1,6-, 1,7-, and 1,8-naphthyridin-2-ones as well as 6-chloroquinolin-2-one.The regiospecific ortho metalation and subsequent formylation of 2-, 3-, or 4-(pivaloylamino)pyridines provides the corresponding protected ortho aminopyridinecarboxaldehydes as key intermediates in this procedure.After condensation of these aldehydes with tert-butyl lithioacetate the resulting beta-hydroxy esters are treated with refluxing aqueous HCl to generate the naphthyridine system in excellent yield.Naphthyridines with diverse substitution patterns in eighter of the pyridine rings are available by appropriate modification of the overall pyridine annulation sequence.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 15944-34-0. In my other articles, you can also check out more blogs about 15944-34-0
Reference£º
1,522-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N516 – PubChem