Month: February 2023

ALSUntangled 57: Vinpocetine was written by Bedlack, Richard;Armon, Carmel;Barkhaus, Paul;Barnes, Benjamin;Bereman, Michael;Bertorini, Tulio;Carter, Greg;Chen, Amy;Crayle, Jesse;Cudkowicz, Merit;Jackson, Carlayne;Kiernan, Matthew;Levitsky, Gleb;McDermott, Christopher;Pattee, Gary;Pioro, Erik;Salmon, Kristiana;Staats, Kim;Stephens, James;Wicks, Paul. And the article was included in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration in 2021.Recommanded Product: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate This article mentions the following:

Vinpocetine (chem. name 14-ethoxycarbonyl- (3a,16a-ethyl)-14,15-eburnamine) is a product derived from an alkaloid substance in the periwinkle plant Vinca minor (2). In many countries it is classified as a prescription drug and is used for the treatment of acute stroke and cognitive impairment(3). Systematic reviews have failed to confirm any benefits for patients with these conditions (4,5). In the Unites States, it is classified as a nutritional supplement (3). At least one website claims that Vinpocetine might be “beneficial for ALS” (6). A published case series demonstrated that Vinpocetine was associated with reduced cramping in PALS and suggested further study, including determining whether it could slow ALS progression (7). This review examines Vinpocetine′s potential role in slowing ALS progression. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Recommanded Product: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Recommanded Product: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Development of a Microencapsulated Medicinal Form of Vinpocetine for Administration by Inhalation was written by Penkina, Yu. A.;Pavlovskaya, O. P.;Avramenko, G. V.. And the article was included in Pharmaceutical Chemistry Journal in 2017.Electric Literature of C22H26N2O2 This article mentions the following:

A method for the microencapsulation of vinpocetine by solvent evaporation in polylactide (PLA) shells with different mol. weights using a mixture of polyvinyl alc. (PVA) and dioctylsulfosuccinate sodium (Aerosol OT, AOT) at a mass ratio of 1:1 as stabilizer was developed. Microencapsulation efficiency was found to increase when PLA with higher mol. weight was used, though the process was essentially independent of the quantity used. Microcapsule dispersity was evaluated. The best samples were obtained using PLA with a mol. weight of 30,500 Da and a vinpocetine:PLA mass ratio of 1:10. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Electric Literature of C22H26N2O2).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Electric Literature of C22H26N2O2

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Olefin Oxygenation by Water on an Iridium Center was written by Ghatak, Tapas;Sarkar, Mithun;Dinda, Shrabani;Dutta, Indranil;Rahaman, S. M. Wahidur;Bera, Jitendra K.. And the article was included in Journal of the American Chemical Society in 2015.Recommanded Product: 1772625-41-8 This article mentions the following:

Oxygenation of 1,5-cyclooctadiene (COD) is achieved on an Ir center using H₂O as a reagent. A H-bonding interaction with an unbound N atom of the naphthyridine-based ligand architecture promotes nucleophilic attack of H₂O to the metal-bound COD. Irida-oxetane and oxo-irida-allyl compounds are isolated, products which are normally accessed from reactions with H₂O₂ or O₂. DFT studies support a ligand-assisted H₂O activation mechanism. In the experiment, the researchers used many compounds, for example, (S)-4-Benzyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole (cas: 1772625-41-8Recommanded Product: 1772625-41-8).

(S)-4-Benzyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole (cas: 1772625-41-8) belongs to naphthyridine derivatives. Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological activities. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Recommanded Product: 1772625-41-8

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Non-catalytic allostery in α-TAT1 by a phospho-switch drives dynamic microtubule acetylation was written by Roy, Abhijit Deb;Gross, Evan G.;Pillai, Gayatri S.;Seetharaman, Shailaja;Etienne-Manneville, Sandrine;Inoue, Takanari. And the article was included in Journal of Cell Biology in 2022.Recommanded Product: 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid This article mentions the following:

Spatiotemporally dynamic microtubule acetylation underlies diverse physiol. and pathol. events. Despite its ubiquity, the mol. mechanisms that regulate the sole microtubule acetylating agent, α-tubulin-N-acetyltransferase1 (α-TAT1), remain obscure. Here, we report that dynamic intracellular localization of α-TAT1 along with its catalytic activity determines efficiency of microtubule acetylation. Specifically, we newly identified a conserved signal motif in the intrinsically disordered C-terminus of α-TAT1, consisting of three competing regulatory elements-nuclear export, nuclear import, and cytosolic retention. Their balance is tuned via phosphorylation by CDK1, PKA, and CK2, and dephosphorylation by PP2A. While the unphosphorylated form binds to importins and resides both in cytosol and nucleus, the phosphorylated form binds to specific 14-3-3 adapters and accumulates in the cytosol for maximal substrate access. Unlike other mols. with a similar phospho-regulated signal motif, α-TAT1 uniquely uses the nucleus as a hideout. This allosteric spatial regulation of α-TAT1 function may help uncover a spatiotemporal code of microtubule acetylation in normal and aberrant cell behavior. In the experiment, the researchers used many compounds, for example, 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6Recommanded Product: 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid).

5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. Halogen atoms attached to the naphthyridine moiety can be easily replaced by other nucleophiles such as alkoxides and amines.Recommanded Product: 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Advances in the chemistry of naphthyridines was written by Litvinov, V. P.. And the article was included in Advances in Heterocyclic Chemistry in 2006.Computed Properties of C8H6N2 This article mentions the following:

A review in which an anal. is made of the synthesis and properties of 6 isomeric heterocyclic systems containing 2 fused pyridine rings with different mutual arrangements of N atoms, naphthyridines (pyridopyridines, diazanaphthalenes). In the experiment, the researchers used many compounds, for example, 2,6-Naphthyridine (cas: 253-50-9Computed Properties of C8H6N2).

2,6-Naphthyridine (cas: 253-50-9) belongs to naphthyridine derivatives. Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6, 1,7, 1,8, 2,6, or 2,7 positions. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves. The corresponding thiazolonaphthyridine is obtained from a similar reaction using 2-aminoethanethiol and Dowex basic anion-exchange resin.Computed Properties of C8H6N2

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Aromaticity of heterocycles containing the imine nitrogen was written by Hess, B. A. Jr.;Schaad, L. J.;Holyoke, C. W. Jr.. And the article was included in Tetrahedron in 1975.Recommanded Product: 2,6-Naphthyridine This article mentions the following:

The method of predicting aromaticity based on simple Heuckel calculations was applied to heterocyclic systems containing imine N. The necessary heteroatomic integrals were determined from thermochem. data. Replacement of C by N in alternant systems, e.g. benzene and pyridine, produced little change but in nonalternants, e.g. pentalene and azapentalene, the effect was large, and interesting synthetic possibilities were suggested. In the experiment, the researchers used many compounds, for example, 2,6-Naphthyridine (cas: 253-50-9Recommanded Product: 2,6-Naphthyridine).

2,6-Naphthyridine (cas: 253-50-9) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Recommanded Product: 2,6-Naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem