An eco-sustainable green approach for the synthesis of 2,6-naphthyridines under microwave irradiation was written by Srivastava, K. P.;Singh, Indu;Kumari, Anupma. And the article was included in Pharma Chemica in 2014.Application In Synthesis of 2,6-Naphthyridine This article mentions the following:
A microwave-promoted new easy, efficient, clean and environmentally benign method for the synthesis of 2,6-naphthyridine and its derivatives from 4-cyano-3-pyridylacetonitrile has been developed. The desired products were isolated in excellent yields and high purity under eco-friendly conditions. In the experiment, the researchers used many compounds, for example, 2,6-Naphthyridine (cas: 253-50-9Application In Synthesis of 2,6-Naphthyridine).
2,6-Naphthyridine (cas: 253-50-9) belongs to naphthyridine derivatives. The naphthyridine ring system, being very π-deficient, is highly vulnerable towards nucleophilic attack, and consequently there has been extensive investigation of reactions involving nitrogen nucleophiles. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves.Application In Synthesis of 2,6-Naphthyridine
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem