Reactions of 1,5- and 1,8-naphthyridine 1-oxides with phosphorus oxide tribromide was written by Czuba, Wladyslaw;Grzegozek, Maria. And the article was included in Universitatis Iagellonicae Acta Chimica in 1991.Electric Literature of C8H4Br2N2 This article mentions the following:
Reactions of 1,5- and 1,8-naphthyridine 1-oxides and 1,5-naphthyridine 1,5-dioxide with POBr3 were studied. The characteristic feature of these reactions was high contribution of unsubstituted naphthyridines and 3-bromo derivatives, apart from 2- and 4-bromonaphthyridines, in the reaction products. In the experiment, the researchers used many compounds, for example, 3,7-Dibromo-1,5-naphthyridine (cas: 17965-72-9Electric Literature of C8H4Br2N2).
3,7-Dibromo-1,5-naphthyridine (cas: 17965-72-9) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Electric Literature of C8H4Br2N2
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem