The Global Phosphorylation Landscape of SARS-CoV-2 Infection was written by Bouhaddou, Mehdi;Memon, Danish;Meyer, Bjoern;White, Kris M.;Rezelj, Veronica V.;Correa Marrero, Miguel;Polacco, Benjamin J.;Melnyk, James E.;Ulferts, Svenja;Kaake, Robyn M.;Batra, Jyoti;Richards, Alicia L.;Stevenson, Erica;Gordon, David E.;Rojc, Ajda;Obernier, Kirsten;Fabius, Jacqueline M.;Soucheray, Margaret;Miorin, Lisa;Moreno, Elena;Koh, Cassandra;Tran, Quang Dinh;Hardy, Alexandra;Robinot, Remy;Vallet, Thomas;Nilsson-Payant, Benjamin E.;Hernandez-Armenta, Claudia;Dunham, Alistair;Weigang, Sebastian;Knerr, Julian;Modak, Maya;Quintero, Diego;Zhou, Yuan;Dugourd, Aurelien;Valdeolivas, Alberto;Patil, Trupti;Li, Qiongyu;Huttenhain, Ruth;Cakir, Merve;Muralidharan, Monita;Kim, Minkyu;Jang, Gwendolyn;Tutuncuoglu, Beril;Hiatt, Joseph;Guo, Jeffrey Z.;Xu, Jiewei;Bouhaddou, Sophia;Mathy, Christopher J. P.;Gaulton, Anna;Manners, Emma J.;Felix, Eloy;Shi, Ying;Goff, Marisa;Lim, Jean K.;McBride, Timothy;O’Neal, Michael C.;Cai, Yiming;Chang, Jason C. J.;Broadhurst, David J.;Klippsten, Saker;De wit, Emmie;Leach, Andrew R.;Kortemme, Tanja;Shoichet, Brian;Ott, Melanie;Saez-Rodriguez, Julio;tenOever, Benjamin R.;Mullins, R. Dyche;Fischer, Elizabeth R.;Kochs, Georg;Grosse, Robert;Garcia-Sastre, Adolfo;Vignuzzi, Marco;Johnson, Jeffery R.;Shokat, Kevan M.;Swaney, Danielle L.;Beltrao, Pedro;Krogan, Nevan J.. And the article was included in Cell (Cambridge, MA, United States) in 2020.Synthetic Route of C19H12ClN3O2 This article mentions the following:
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here, we present a quant. mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins. SARS-CoV-2 infection promoted casein kinase II (CK2) and p38 MAPK activation, production of diverse cytokines, and shutdown of mitotic kinases, resulting in cell cycle arrest. Infection also stimulated a marked induction of CK2-containing filopodial protrusions possessing budding viral particles. Eighty-seven drugs and compounds were identified by mapping global phosphorylation profiles to dysregulated kinases and pathways. We found pharmacol. inhibition of the p38, CK2, CDK, AXL, and PIKFYVE kinases to possess antiviral efficacy, representing potential COVID-19 therapies. In the experiment, the researchers used many compounds, for example, 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6Synthetic Route of C19H12ClN3O2).
5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Synthetic Route of C19H12ClN3O2
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem