Impact of Affecting the Formation Defects in Vinpocetine Crystals was written by Yu, Zengrui;Wang, Yongli;Du, Shichao;Zhou, Jing;Zhou, Lina. And the article was included in Crystal Growth & Design in 2020.Recommanded Product: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate This article mentions the following:
Combined with rigorous and accurate exptl. protocols, the key influencing factors of the formation of macroscopic defects in vinpocetine (VIP) solution were studied with the aim to propose a universal strategy toward the inquiry of the formation mechanism of crystal defects in organic crystals. By screening solvents and polymorphism, it was determined that vinpocetine has two crystal habits (habits I & II); the content and formation mechanism of the defects in two crystal habits was confirmed to be disparate. The impacts of temperature, supersaturation, agitation, and ultrasound on the defects of the habit I were investigated in a targeted manner. The crystal surface indexation method was used to visually analyze the growth behavior of VIP single crystals. It was revealed that the stepwise lowered layers of {(100)} crystal planes in crystal habit I were primary factors inducing neg. defects formation. In addition, the mol. dynamics simulation was employed to investigate the interactions between the surface of vinpocetine crystal and the pure solvent. The growth rate and surface roughness of the crystal faces were simulated using the modified attachment energy model. Through the discussion of surface structure and adsorption mechanism, it was expounded that the crystal growth kinetics induced the formation of depressions and further contributes to the formation of defects in cavities and fine inclusions. In this work, two crystal habits of vinpocetine were screened and characterized. Various influencing factors of crystal defect formation were investigated. The mechanism of crystal defect formation of vinpocetine was proposed in combination with computer simulation. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Recommanded Product: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate).
(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6, 1,7, 1,8, 2,6, or 2,7 positions. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Recommanded Product: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem