Development of a Microencapsulated Medicinal Form of Vinpocetine for Administration by Inhalation was written by Penkina, Yu. A.;Pavlovskaya, O. P.;Avramenko, G. V.. And the article was included in Pharmaceutical Chemistry Journal in 2017.Electric Literature of C22H26N2O2 This article mentions the following:
A method for the microencapsulation of vinpocetine by solvent evaporation in polylactide (PLA) shells with different mol. weights using a mixture of polyvinyl alc. (PVA) and dioctylsulfosuccinate sodium (Aerosol OT, AOT) at a mass ratio of 1:1 as stabilizer was developed. Microencapsulation efficiency was found to increase when PLA with higher mol. weight was used, though the process was essentially independent of the quantity used. Microcapsule dispersity was evaluated. The best samples were obtained using PLA with a mol. weight of 30,500 Da and a vinpocetine:PLA mass ratio of 1:10. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Electric Literature of C22H26N2O2).
(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Electric Literature of C22H26N2O2
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem