Aromaticity of heterocycles containing the imine nitrogen was written by Hess, B. A. Jr.;Schaad, L. J.;Holyoke, C. W. Jr.. And the article was included in Tetrahedron in 1975.Recommanded Product: 2,6-Naphthyridine This article mentions the following:
The method of predicting aromaticity based on simple Heuckel calculations was applied to heterocyclic systems containing imine N. The necessary heteroatomic integrals were determined from thermochem. data. Replacement of C by N in alternant systems, e.g. benzene and pyridine, produced little change but in nonalternants, e.g. pentalene and azapentalene, the effect was large, and interesting synthetic possibilities were suggested. In the experiment, the researchers used many compounds, for example, 2,6-Naphthyridine (cas: 253-50-9Recommanded Product: 2,6-Naphthyridine).
2,6-Naphthyridine (cas: 253-50-9) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Recommanded Product: 2,6-Naphthyridine
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem