Synthesis of 2,6-naphthyridine was written by Giacomello, G.;Gualtieri, F.;Riceieri, F. M.;Stein, M. L.. And the article was included in Tetrahedron Letters in 1965.Name: 2,6-Naphthyridine This article mentions the following:
Transformation of 4-carbethoxynicotinic acid via the acid chloride, b0.1 102°, gave Et β-diazoacetylisonicotinate (I), m. 58-60° (Et2O). I treated with Ag2O in absolute alc. with rearrangement and loss of N gave di-Et β-homocinchomeronate (II), b0.05 116-17°; picrate m. 104-6°. II kept several days with alc. NH4OH in a sealed tube and heated at 100° gave the diamide, converted by heating above the m.p. at 177-82° to give the imide (III), m. 229-30° (H2O). III kept several hrs. at 120° in a sealed tube with POCl3 gave 1,3-dichloro-2,6-naphthyridine (IV), m. 116° (petr. ether), converted to the 1,3-dihydrazine derivative, m. 300°. The dihydrazine in H2O-AcOH heated with 10% CuSO4 solution on a steam bath and the mixture made alk. with 5N NaOH, extracted with CH2Cl2 and the dried (Na2SO4) extract evaporated gave a solid, sublimed at 60°/0.1 mm. to yield 2,6-naphthyridine, m. 114-15°; monopicrate m. 206° (alc.). Attempted hydrogenolysis of IV with H over prereduced PtO2 gave 5,6,7,8-tetrahydro-1,3-dichloro-2,6-naphthyridine, m. 125-7° (petr. ether). III mixed with Zn dust and heated at 170° in a sealed tube also gave 2,6-naphthyridine in poorer yields. Spectral data are given. In the experiment, the researchers used many compounds, for example, 2,6-Naphthyridine (cas: 253-50-9Name: 2,6-Naphthyridine).
2,6-Naphthyridine (cas: 253-50-9) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Name: 2,6-Naphthyridine
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem