Month: December 2022

Zheng, Yajuan published the artcileAn improvement of the method for measurements of silicon content in water for laboratory use, Safety of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is Guangdong Huagong (2012), 39(1), 105, 86, database is CAplus.

Platinum crucible intended for determination silicon content in water suffers from several disadvantages that it is very costly, difficult to preserve and not widely accessible. In the paper, the method adopted Teflon pot to replace Platinum crucible in the process of evaporation and condensation can satisfy the requirements of accuracy and precision, meanwhile, the approach utilization Teflon pot is cost-effective and time-saving.

Guangdong Huagong published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C7H16ClNO2, Safety of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Middleton, William J. published the artcileNew fluorinating reagents. Dialkylaminosulfur fluorides, Related Products of naphthyridine, the publication is Journal of Organic Chemistry (1975), 40(5), 574-8, database is CAplus.

Trifluorides R2NSF3 (I; R = Me, Et, Me2CH; or R2N = pyrrolidino) were prepared by the reaction of R2NSiMe3 with SF4 in FCCl3 at -78°; I reacted with R21NSiMe3 to give R2NSF2NR21 (II; R, R1 = Me, Et; or R12 = piperidino). I and II were used to fluorinate alcs., aldehydes, or ketones. E.g., I (R = Et) reacted with Me2CHCH2OH in diglyme at -50 to -78° to give 49% Me2CHCH2F and 21% Me3CF. EtCHO with I (R = Et) in FCCl3 at 25° gave 80% EtCHF2. Among ∼23 other compounds fluorinated were: cyclooctanol, BzH, 1-naphthaldehyde, and menthol.

Journal of Organic Chemistry published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Masuda, Yasusuke published the artcileIntrahepatic flow disturbance: possibility of a hidden cause of drug toxicity, Synthetic Route of 59973-80-7, the publication is Journal of Pharmacological Sciences (Tokyo, Japan) (2006), 100(3), 167-174, database is CAplus and MEDLINE.

The liver has an intricate microvascular system that allows homogenous perfusion throughout the organ. However, the regulatory mechanisms of intrahepatic circulation are still unclear, and the effects of drugs on this system have rarely been reported. Oxethazaine, a topical anesthetic, was incidentally found to induce a consistent increase in portal pressure in the isolated perfused rat liver, which led us to characterize this phenomenon. For this, a vital staining method was developed to detect microcirculatory alterations in the isolated liver. Using this method, not only vasoconstrictors like endothelin-1, but the drugs oxethazaine and clomipramine, a tricyclic antidepressant, were found to induce flow redistribution to the deeper and hilar portions of the liver with minimal perfusion at the periphery, which was due to a short-circuit flow at the center owing to the constriction of the intrahepatic portal vein branches. Hepatic nerve stimulation also produced a similar flow disturbance. Since the portal pressure increases by these compounds were inhibited by the Rho-kinase inhibitors Y27632 and HA1077, portal vein branches may employ a Rho-kinase-dependent pathway for sustained contraction. However, oxethazaine, clomipramine, and endothelin-1 may activate this pathway differently. The intrahepatic flow disturbance could play a hidden role in drug toxicity of certain drugs.

Journal of Pharmacological Sciences (Tokyo, Japan) published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Synthetic Route of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Malkinson, Alvin M. published the artcileRole of inflammation in mouse lung tumorigenesis: a review, Application of Sulindac sulfone, the publication is Experimental Lung Research (2005), 31(1), 57-82, database is CAplus and MEDLINE.

A review. Peritumoral and intratumoral macrophages are associated with human and mouse lung cancer. The mouse model allows manipulation of the macrophage population to exptl. evaluate its contribution to tumor growth. Genetic and pharmacol. strategies also permit testing the involvement of specific inflammatory mediators in tumor progression. Among those endogenous mediators thus identified are interleukin (IL)-10, glucocorticoids, prostacyclin, nitric oxide, and surfactant apoprotein D (SP-D); serum SP-D levels are a useful biomarker to monitor tumor growth rate. The importance of understanding the mutually antagonistic roles of individual prostaglandins downstream from cycloxygenase (COX) and how this affects the efficacy of COX-inhibitory drugs is discussed. Promising drug candidates include synthetic glucocorticoids such as budesonide and the sulfone derivative of sulindac, apotosyn.

Experimental Lung Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Application of Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Levine, Lawrence published the artcileDoes the release of arachidonic acid from cells play a role in cancer chemoprevention?, Recommanded Product: Sulindac sulfone, the publication is FASEB Journal (2003), 17(8), 800-802, database is CAplus and MEDLINE.

COX-2 is overexpressed in cancer cells and has become a major target for cancer preventive drugs. NSAIDs, retinoids, antioxidants, and PPAR agonists, reported to be chemopreventive, suppress COX-2 synthesis. NSAIDs also have been shown to be chemopreventive independent of COX-2 activity. Common to all of these compounds is their ability to release arachidonic acid (AA) from rat liver cells in culture. Most of these compounds inhibit induced PGI₂ production Vitamin D₃ and tamoxifen, however, not only stimulate the release of AA from cells: they amplify rather than inhibits induced COX activity. In view of the many activities attributable to AA, I propose that its release and accumulation could initiate mol. reactions that lead to apoptosis and eventually to suppression of cancer. Some drugs shown to release AA from cells and affect PGI₂ production-e.g., thiazolidinediones and statins are widely used for conditions unrelated to cancer. In vivo studies could reveal whether they can also function as cancer preventive agents.

FASEB Journal published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Recommanded Product: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Karaman, Yeliz published the artcileInvestigation of electrochemical behavior of Calmagite at a glassy carbon electrode, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is Dyes and Pigments (2014), 39-44, database is CAplus.

The voltammetric behavior of 1-(1-hydroxy-4-methyl-2-phenylazo)-2-naphthol-4-sulfonic acid (Calmagite) was studied by square-wave voltammetry (SWV), differential pulse voltammetry (DPV), cyclic voltammetry (CV) and d.c. voltammetry (DCV) in different electrolyte media. The voltammograms recorded at a glassy C electrode (GCE) exhibit one cathodic peak, corresponding to the two-step four-electron reduction process of azo compound The observed shift of the compound reduction peaks to more neg. potentials with increasing pH indicates that H ions are involved in the electrode reaction. The effect of scan rate and pH on the reduction peaks was studied. From the voltammetric data, the electrochem. reaction mechanism of the azo compound was suggested.

Dyes and Pigments published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Hendricker, David G. published the artcileComplexes of 1,8-naphthyridines. II. Dialkyltin dichloride adducts of 2,7-dimethyl-1,8-naphthyridine, Name: 2,7-Dimethyl-1,8-naphthyridine, the publication is Inorganic Chemistry (1969), 8(11), 2328-30, database is CAplus.

Complexes of the type R2SnCl2L, where R = Me, Et, Pr, Bu, C5H11, Ph, C12H25, and Cl and L = 2,7-dimethyl-1,8-naphthyridine, have been prepared and characterized. A 4-member chelate ring system is exhibited in these white, air-stable complexes. The ir spectra (600-200 cm.-1) of the compounds have been recorded and assignment of the Sn-Cl and Sn-C stretching modes made. The changes in ligand and alkyltin proton magnetic resonance positions produced by complexation are examined The 117Sn-H and 119Sn-H coupling constants for the compounds, where R = Me and Et, are reported. A cis-Cl,-trans-R geometry for these complexes is inferred from the spectral data.

Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Name: 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Galmarini, Carlos M. published the artcileOSI-461 (OSI), COA of Formula: C20H17FO4S, the publication is Current Opinion in Investigational Drugs (Thomson Scientific) (2004), 5(6), 648-656, database is CAplus and MEDLINE.

A review. OSI Pharmaceuticals is developing OSI-461, a potent analog of exisulind, for the potential treatment of cancer and inflammatory bowel disease. In August 2001, OSI-461 entered phase II trials involving patients with chronic lymphocytic leukemia. In July 2002, the company embarked on a pilot phase II study evaluating OSI-461 for the treatment of Crohn’s disease. By Oct. 2002, Cell Pathways had selected hormone-refractory prostate cancer as the lead cancer indication for clin. development of OSI-461.

Current Opinion in Investigational Drugs (Thomson Scientific) published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, COA of Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

El-Dossoki, Farid I. published the artcileProtonation and solvation thermodynamics of some naphthol derivatives in KCl aqueous solution of different ionic strengths, Computed Properties of 116-63-2, the publication is Journal of Chemistry (2016), 7234320/1-7234320/8, database is CAplus.

The acid-base properties of naphthalen-1-ol (L1), naphthalene-1,5-diol (L2), and 4-amino-3-hydroxynaphthalene-1-sulfonic acid (L3) were characterized from pH-metric measurements in pure water and in different concentrations (0-4 mol kg^-1) of aqueous KCl solutions at the temperature range of T = (293.15 to 213.15)K at 5K intervals. The results reveal that naphthalen-1-ol and naphthalene-1,5-diol mols. have two ionizable protons (of the hydroxyl groups) while 4-amino-3-hydroxynaphthalene-1-sulfonic acid has three ionizable protons (hydrogen ion of the hydroxyl group, SO³H, and NH₃⁺). Modeling of the data was done by applying Debye-Hoeckel model.The protonation and the solvation processes of all studied ligands are spontaneous and endothermic processes. Also the solubilities of naphthalen-1-ol, naphthalene-1,5-diol, and 4-amino-3-hydroxynaphthalene-1-sulfonic acid were determined The data were analyzed using Setschenow equation and the values of Setschenow coefficients (K_m) were determined From the solubility data, the activity coefficients were obtained. The values of the total solubilities (ST) for naphthalen-1-ol and naphthalene-1,5-diol were found equal to the values of their neutral species (S⁰). On the other hand, the total solubility for 4-amino-3-hydroxynaphthalene-1-sulfonic acid is different from that of its neutral species.The results also indicate solubility decrease in pure water from L1-L2-L3.

Journal of Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Deady, Leslie W. published the artcileA search for lone-pair interactions in forward and reverse Menshutkin reactions of some diaza heterocycles, Application of 2,7-Dimethyl-1,8-naphthyridine, the publication is Australian Journal of Chemistry (1981), 34(1), 163-70, database is CAplus.

The rates of methylation (forward reaction) of phthalazine (I), 1,8-naphthyridine (II), 1,10-phenanthroline (III), and some ring-methylated derivatives are compared with the rates of demethylation of the corresponding N-Me quaternary iodides. In II, and especially in III, an N lone pair in place of a CH group (quinoline and 8-methylquinoline, resp.) aids the forward reaction but does not retard the reverse process. In contrast to III, 2,2′-bipyridine showed behavior typical of α-substituted pyridines. The introduction of a 2-Me group into III had an appreciable rate-enhancing effect on methylation (at N-10), which is interpreted as evidence for lone-pair cooperativity in the forward reaction.

Australian Journal of Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Application of 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem