Month: December 2022

Wu, Wei published the artcileSpectrophotometric determination of trace nitrite with a novel self-coupling diazotizing reagent: J-acid, Quality Control of 116-63-2, the publication is Khimiya i Tekhnologiya Vody (2015), 37(6), 545-554, database is CAplus.

A simple and sensitive method for the spectrophotometric determination of nitrite was described and optimum reaction conditions along with other important anal. parameters were established. In the presence of potassium bromide at 25°C, nitrite reacted with J-acid in hydrochloric acid producing diazonium salt and then coupled with excess J-acid in the sodium carbonate solution yielding red colored azo compounds At wavelength of 500 nm, Beer’s law was obeyed over the concentration range of 0,02-0,60 mg·L^-1. The molar absorptivity was 3,92·10⁴ L·mol^-1·cm^-1. This method was easily applied to the determination of trace nitrite in environmental water with recoveries of 98,7-101,2%.

Khimiya i Tekhnologiya Vody published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C17H18N3NaO3S, Quality Control of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Cao, Ye published the artcileThe oxidative degradation of Calmagite using added and in situ generated hydrogen peroxide catalysed by manganese(II) ions: Efficacy evaluation, kinetics study and degradation pathways, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is Chemosphere (2022), 286(Part_2), 131792, database is CAplus and MEDLINE.

Manganese (II) ions (Mn(II)) catalyze the oxidative degradation of Calmagite (CAL, 2-hydroxy-1-(2-hydroxy-5methylphenylazo)-4-naphthalenesulfonic acid) at room temperature using added and in situ generated hydrogen peroxide (H₂O₂), using 1,2-dihydroxybenzene-3,5-disulfonate, disodium salt and monohydrate (Tiron) as the co-catalyst for the in situ generation of H₂O₂. The percentage of CAL degradation with the in situ generated H2O2 was 91.1% after 30 min which is lower than that in the added H₂O₂/Mn(II) system (96.0%). A one-eighth-lives method was applied to investigate the kinetic parameters in the added H₂O₂ system, with and without Mn(II), involving phosphate, carbonate, and two biol. buffers at different pHs. Percarbonate (HCO^–₄) was found to be the main reactive species for CAL degradation in the added H₂O₂ system buffered by carbonate in the absence of Mn(II). Manganese (IV) = O (Mn(IV) = O) and manganese(V) = O (Mn(V) = O) are the main reactive species in the added H2O2/Mn(II) system buffered by carbonate and non-carbonate buffers resp. pH 8.5 was the optimum pH for CAL degradation when buffered by carbonate, while pH 10.0 is the best pH for the systems not using carbonate buffer. Using a high performance liquid chromatog./electrospray ionisation mass spectrometer (HPLC/ESI-MS), the degradation intermediates of CAL were identified as 1-amino-2-naphthol-4-sulfonate ion, 1-amino-2-naphthol-4-sulfinic ion, 1-amino-2-naphthol, and 1-nitroso-2-naphthol.

Chemosphere published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Tang, Weijuan published the artcileGas-phase ion-molecule reactions for the identification of the sulfone functionality in protonated analytes in a linear quadrupole ion trap mass spectrometer, Application In Synthesis of 59973-80-7, the publication is Rapid Communications in Mass Spectrometry (2016), 30(12), 1435-1441, database is CAplus and MEDLINE.

Rationale : The oxidation of sulfur atoms is an important biotransformation pathway for many sulfur-containing drugs. In order to rapidly identify the sulfone functionality in drug metabolites, a tandem mass spectrometric method based on ion-mol. reactions was developed. Methods : A phosphorus-containing reagent, tri-Me phosphite (TMP), was allowed to react with protonated analytes with various functionalities in a linear quadrupole ion trap mass spectrometer. The reaction products and reaction efficiencies were measured. Results : Only protonated sulfone model compounds were found to react with TMP to form a characteristic [TMP adduct-MeOH] product ion. All other protonated compounds investigated, with functionalities such as sulfoxide, N-oxide, hydroxylamino, keto, carboxylic acid, and aliphatic and aromatic amino, only react with TMP via proton transfer and/or addition The specificity of the reaction was further demonstrated by using a sulfoxide-containing anti-inflammatory drug, sulindac, as well as its metabolite sulindac sulfone. Conclusions : A method based on functional group-selective ion-mol. reactions in a linear quadrupole ion trap mass spectrometer has been demonstrated for the identification of the sulfone functionality in protonated analytes. A characteristic [TMP adduct-MeOH] product ion was only formed for the protonated sulfone analytes. The applicability of the TMP reagent in identifying sulfone functionalities in drug metabolites was also demonstrated. Copyright © 2016 John Wiley & Sons, Ltd.

Rapid Communications in Mass Spectrometry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C26H45N5O7Si2, Application In Synthesis of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Liu, Yan published the artcileRigid chelating dicarbene ligands based on naphthyridine-fused bisimidazolium salts, Recommanded Product: 2,7-Dimethyl-1,8-naphthyridine, the publication is Chinese Chemical Letters (2022), 33(6), 2993-2996, database is CAplus.

Naphthyridine-fused bisimidazolium salts were designed and synthesized for the first time. The study of the Cu(II) and Pd(II) complexes demonstrated that the deprotonated dicarbene ligands are rigid chelating C,C-ligands with strong electron-donating ability in analogy with the classic phenanthroline N,N-ligands.

Chinese Chemical Letters published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Recommanded Product: 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Genaev, Alexander M. published the artcileAcid-Catalyzed Versus Thermally Induced C1-C1′ Bond Cleavage in 1,1′-Bi-2-naphthol: An Experimental and Theoretical Study, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Journal of Organic Chemistry (2019), 84(11), 7238-7243, database is CAplus and MEDLINE.

Experiments show that 1,1′-bi-2-naphthol (BINOL) undergoes facile C1-C1′ bond cleavage under action of triflic acid at temperatures above 0 °C to give mainly 2-naphthol along with oligomeric material. CASSCF and MRMP//CASSCF computations have demonstrated unambiguously that this unusual mode of scission of the biaryl bond can occur in the C1,C1′-diprotonated form of BINOL via a mechanism involving homolytic cleavage prompted by the intramol. electrostatic repulsion. These findings also provide insights into the mechanism of a comparatively easy thermal cleavage of BINOL, implying the intermediacy of its neutral diketo form.

Journal of Organic Chemistry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Recommanded Product: 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Huang, Wei-Hua published the artcileSimultaneous determination of sulindac and its metabolites sulindac sulfide and sulindac sulfone in human plasma by a sensitive UPLC-PDA method for a pharmacokinetic study, Synthetic Route of 59973-80-7, the publication is Analytical Methods (2014), 6(13), 4679-4685, database is CAplus.

A sensitive, rapid and reliable ultra-performance liquid chromatog. (UPLC) with Photo-Diode Array (PDA) detection method was developed for simultaneous determination of sulindac and its metabolites sulindac sulfide and sulindac sulfone in human plasma. The analytes were extracted by dichloromethane from human plasma using a liquid-liquid extraction method. The chromatog. separation was performed on a Waters Acquity UPLC with a Waters Acquity UPLC BEH C₁₈ column (2.1 × 50 mm i.d., 1.7 μm) within 5 min. The mobile phase used for gradient elution consisted of ammonium formate buffer (20 mM) containing 1% acetic acid and acetonitrile. The flow rate was maintained at 0.4 mL min^-1. The monitor wavelength was set at 328 nm for PDA detection. All calibration curves of the analytes showed good linearity within the test ranges. The validated method was successfully applied to a pharmacokinetic study of sulindac, sulindac sulfide and sulindac sulfone in 15 healthy Chinese male subjects with oral administration of sulindac tablets.

Analytical Methods published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Synthetic Route of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Gole, Bappaditya published the artcileSupramolecular polymer for explosives sensing: role of H-bonding in enhancement of sensitivity in the solid state, HPLC of Formula: 18512-55-5, the publication is Chemical Communications (Cambridge, United Kingdom) (2011), 47(36), 10046-10048, database is CAplus and MEDLINE.

A π-electron rich supramol. polymer as an efficient fluorescent sensor for electron deficient nitroarom. explosives was synthesized, and the role of H-bonding in dramatic amplification of sensitivity/fluorescence quenching efficiency in the solid state is established.

Chemical Communications (Cambridge, United Kingdom) published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, HPLC of Formula: 18512-55-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Pavadai, Parasuraman published the artcileSynthesis, characterization and antimalarial evaluation of some substituted 4-aminocinnoline-3-carboxamide derivatives, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, the publication is International Journal of Pharmaceutical Chemistry (2011), 1(2), 39-44, database is CAplus.

A series of 7-substituted-4-aminocinnoline-3-carboxamide were synthesized from 7-chloro-4-aminocinnoline-3-carboxamide treated with substituted aryl amine under phase transfer catalysis condition. The structure of the compounds were characterized by UV, IR, NMR and mass spectral data, and evaluated for their in vitro antimalarial. All analogs showed in vitro antimalarial activity against Plasmodium falciparum.

International Journal of Pharmaceutical Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Application of 4-Amino-3-hydroxynaphthalene-1-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Parasuraman, Pavadai published the artcileSynthesis, characterization and antimicrobial evaluation of some substituted 4-aminocinnoline-3-carboxamide derivatives, Quality Control of 116-63-2, the publication is International Journal of Pharmacy and Life Sciences (2012), 3(2), 1430-1436, database is CAplus.

A series of 7-substituted-4-aminocinnoline-3-carboxamide were synthesized from 7-chloro-4-aminocinnoline-3-carboxamide treated with substituted aryl amines under phase transfer catalysis condition. The structure of the compounds were characterized by UV, IR, NMR and mass spectral data, and evaluated for their in vitro antimalarial, antibacterial, and antifungal activity. All analogs showed in vitro antimalarial activity against Plasmodium falciparum, and all the analogs showed antibacterial and antifungal activity in various microbes.

International Journal of Pharmacy and Life Sciences published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Quality Control of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

W-Radhi, Sami published the artcilePreparation and use of a new organic reagent of 4-(furan-2-yldiazenyl)-3-hydroxy naphthalene-1-sulfonic acid (FDHNSA) in an analytical study of some metal ions and drugs, such as salbutamol (SAL) and methyldopa (MDP), Category: naphthyridine, the publication is Research Journal of Pharmaceutical, Biological and Chemical Sciences (2022), 13(3), 170-180, database is CAplus.

This study includes the synthesis of organic reagent 4-(Furan-2-yldiazenyl)-3-hydroxy naphthalene-1-sulfonic acid (FDHNSA) by reacting a diazonium Salt (4-amino-3-hydroxy naphthalene-1-sulfonic aciel) with Furan in alk. ethanol solution The prepared reagent was identified by using (UV-Vis), (FT.IR), (H1NMR) techniques, it was λmax = 412 nm for the reagent (FD HNSA) in ethanol. The m.p. of reagent (FDANSA) is found to be (129-130)°C. This study tried to find a quick, easy and inexpensive spectral way to detection two kind of drugs, Methyldopa (MDP) and Salbutamol (SAL) through the reaction the drugs with anew regent 4-(furan-2-yldiazenyl)-3-hydroxynaphthalene-1-sulfonic acid (FDHNSA) in alk. medium. The results a highest absorption for (SAL) with FDHNSA at λmax = 485 nm, while the λmax = 348 nm for SAL in water, the highest absorption for the Free reagent (FDH NSA) λmax = 412 nm in ethanol. This study was conducted to find the optimized Conditions to estimate, the drug (SAL) with the new Reagent (FDHNSA), It was show the Optimized Concentration reagent was equal to (0.023M) and (2.5ml), The volume of drug (SAL) was equal to (1.5ml). The value of pH was equal (11). Added to that the effect of temperature and time were Conducted, a higher absorbance was obtained when temperature At (35°C), while at that best time it was obtained at (15min) for (SAL). The Calibration curve for the durg (SAL) was Constructed after establish the optime conditions. The Calibration Curve was constructed and subsequently the Beer′s Low was obeyed within the Concentration range of SAL (0.75 – 12 μg.ml-1). The Molar absorptivity (ε) Value was equal 1.5802 x 10+4L.mole-1.cm-1. The Sandell′s sensitivity value was equal 0.0365 μg.ml-1. The R.SD% value was equal. 1.230% with a correlation coefficient 0.9995. The stoichiometry of the reaction between the drug (SAL) and reagent (FDHNSA) was proposed with continuous variation and mode ratio methode was (1:1), (SAL:FDHNSA). Finally, interference was studied. The results reveal no effect on the determination of the drug. This methods was success fully applied for the determination of the drugs and in pharmaceutical compounds

Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H12F6N4O6PdS2, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem