Month: December 2022

Agarwal, B. published the artcileCox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cells, COA of Formula: C20H17FO4S, the publication is Apoptosis (2003), 8(6), 649-654, database is CAplus and MEDLINE.

The role of Cox-2 in NSAID-induced apoptosis is debated. We studied the role of Cox-2 inhibition in apoptosis induced by a selective Cox-2 inhibitor, SC 236 (a structural analog of celecoxib) in two colon cancer cell lines, HT29 (expressing Cox-2 protein) and HCT116 (not expressing Cox-2 protein). Apoptosis was quantified by flow cytometry. SC 236 0-75 μM decreased cell numbers and induced apoptosis to identical levels in HT29 and HCT116 cells. However, SC 236, concentrations >75 μM reduced Cox-2 protein expression in HT29 cells and induced greater levels of apoptosis in HT29 than in HCT116 cells. In contrast, sulindac sulfide (SSD) (which inhibits Cox-1 and Cox-2) 0-200 μM or sulindac sulfone (SSN) 0-500 μM (without significant activity against Cox-1 or Cox-2) caused identical decreases in cell number and increases in apoptosis in HT29 and HCT116 cells. Neither SSD nor SSN altered the expression of Cox-2 in HT29 cells. To determine that the higher levels of apoptosis in HT29 cells with SC 236 >75 μM were related to decreased Cox-2 protein levels, we decreased Cox-2 protein expression in HT29 cells with curcumin (diferuloylmethane) and studied its effect on SC 236-induced apoptosis. Curcumin augmented apoptosis induced by SC 236 in HT29 cells but not in Cox-2 lacking HCT116 cells. In conclusion, selective Cox-2 inhibitors can induce apoptosis independent of Cox-2 expression. However they may selectively target cells that express Cox-2 by decreasing their Cox-2 protein expression.

Apoptosis published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, COA of Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Guo, Sheng published the artcileVersatile Porous Poly(arylene ether)s via Pd-Catalyzed C-O Polycondensation, Quality Control of 159-62-6, the publication is Journal of the American Chemical Society (2021), 143(30), 11828-11835, database is CAplus and MEDLINE.

Porous organic polymers (POPs) with strong covalent linkages between various rigid aromatic structural units having different geometries and topologies are reported. With inherent porosity, predictable structure, and tunable functionality, POPs have found utility in gas separation, heterogeneous catalysis, sensing, and water treatment. Poly(arylene ether)s (PAEs) are a family of high-performance thermoplastic materials with high glass-transition temperatures, exceptional thermal stability, robust mech. properties, and excellent chem. resistance. These properties are desirable for development of durable POPs. However, the synthetic methodol. for the preparation of these polymers has been mainly limited in scope to monomers capable of undergoing nucleophilic aromatic substitution (S_NAr) reactions. Herein, we describe a new general method using Pd-catalyzed C-O polycondensation reactions for the synthesis of PAEs. A wide range of new compositions and PAE architectures are now readily available using monomers with unactivated aryl chlorides and bromides. Specifically, monomers with conformational rigidity and intrinsic internal free volume are now used to create porous organic polymers with high mol. weight, good thermal stability, and porosity. The reported porous PAEs are solution processable and can be used in environmentally relevant applications including heavy-metal-ion sensing and capture.

Journal of the American Chemical Society published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C25H16O, Quality Control of 159-62-6.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Grisorio, Roberto published the artcileAll-donor poly(arylene-ethynylene)s containing anthracene and silole-based units: Synthesis, electronic and photovoltaic properties, Recommanded Product: 9,10-Diethynylanthracene, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2013), 51(22), 4860-4872, database is CAplus.

The manuscript deals with the synthesis and properties of four new all-donor alternating poly(arylene-ethynylene)s DBSA, DBSTA, DTSA, and DTSTA. The polymers have been obtained by a Sonogashira cross-coupling of 9,10-diethynyl-anthracene with the dibromo-derivatives of 9,9-dioctyl-dibenzosilole (DBSA), 2,7-dithienyl-9,9-dioctyl-dibenzosilole (DBSTA), 4,4-dioctyl-dithienosilole (DTSA), or 2,6-dithienyl-9,9-dioctyl-dithienosilole (DTSTA). The polymers exhibited absorption profiles and frontier orbital energies strongly dependent on their primary structure. D. functional theory calculations confirmed exptl. observations and provided an insight into the electronic structure of the macromols. In particular, the effects exerted by the thiophene units in DBSTA and DTSTA on the optical properties of the corresponding polymers could be rationalized with respect to DBSA and DTSA. Preliminary photovoltaic measurements have established that the performance of DTSA is among the highest reported for an all-donor polymer. Moreover, UV irradiation of DTSA films under air evidenced a remarkable photostability of this material, providing further evidence that ethynylene-containing electron-rich systems are promising donors for organic solar cells applications. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Recommanded Product: 9,10-Diethynylanthracene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Mukkala, Veli Matti published the artcileNew heteroaromatic complexing agents and luminescence of their europium(III) and terbium(III) chelates, Synthetic Route of 14903-78-7, the publication is Helvetica Chimica Acta (1992), 75(5), 1621-32, database is CAplus.

Twelve heteroaromatic complexing agents were prepared with the purpose to develop suitable labels for time-resolved luminescence-based bioaffinity assays. The relative luminescence yields, excitation maximum, and emission decay constants of their Eu(III) and Tb(III) chelates were determined 2,2′,2”,2”’-[(2,2′-Bipyridine-6,6′-diyl)bis(methylenenitrilo)]tetrakis(acetic acid) and 2,2′,2”,2”’-[(2,2′:6′,2”-terpyridine-6,6”-diyl)bis(methylenenitrilo)]tetrakis(acetic acid) are the most promising agents.

Helvetica Chimica Acta published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Synthetic Route of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Tu, Tao published the artcileRobust Acenaphthoimidazolylidene Palladium Complexes: Highly Efficient Catalysts for Suzuki-Miyaura Couplings with Sterically Hindered Substrates, Application of 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Organic Letters (2012), 14(16), 4250-4253, database is CAplus and MEDLINE.

Robust acenaphthoimidazolylidene palladium complexes I [R = i-Pr, R’= H; R = R’ = Me, H] have been demonstrated as highly efficient and general catalysts for the sterically hindered Suzuki-Miyaura cross-coupling reactions in excellent yields even with low catalyst loadings under mild reaction conditions. The high catalytic activity of these complexes highlights that, besides the “flexible steric bulky” concept, σ-donor properties of the NHC ligands are also crucial to accelerate the transformations.

Organic Letters published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C5H12O2, Application of 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Morioka, Kohei published the artcileSynthesis and chiral recognition ability of optically active poly{N-[(R)-α-methoxycarbonylbenzyl]methacrylamide} with various tacticities by radical polymerization using Lewis acids, Name: 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2003), 41(21), 3354-3360, database is CAplus.

The radical polymerization of an optically active methacrylamide, N-[(R)-α-methoxycarbonylbenzyl]methacrylamide, was carried out in the absence and presence of Lewis acids such as ytterbium trifluoromethanesulfonate [Yb(OTf)₃] and scandium trifluoromethanesulfonate [Sc(OTf)₃]. Catalytic amounts of the Lewis acids significantly affected the stereoregularity of the obtained polymers. The polymerization with Yb(OTf)₃ in THF afforded isotactic polymers (up to mm = 87%), whereas the conventional radical method without the Lewis acid produced polymers rich in syndiotacticity (up to rr = 88%). The radical polymerization in the presence of MgBr₂ proceeded in a heterotactic-selective manner (mr = 63%). Thus, the isotactic, syndiotactic, and heterotactic poly(methacrylamide)s were synthesized by the radical processes. The chiral recognition abilities of the obtained optically active poly(methacrylamide)s were affected by the stereoregularity.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Name: 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zhang, Hong-Tao published the artcileIron-Catalyzed Water Oxidation: O-O Bond Formation via Intramolecular Oxo-Oxo Interaction, Category: naphthyridine, the publication is Angewandte Chemie, International Edition (2021), 60(22), 12467-12474, database is CAplus and MEDLINE.

Herein, we report the importance of structure regulation on the O-O bond formation process in binuclear iron catalysts. Three complexes, [Fe₂(μ-O)(OH₂)₂(TPA)₂]⁴⁺ (1), [Fe₂(μ-O)(OH₂)₂(₆-HPA)]⁴⁺ (2) and [Fe₂(μ-O)(OH₂)₂(BPMAN)]⁴⁺ (3), have been designed as electrocatalysts for water oxidation in 0.1 M NaHCO₃ solution (pH 8.4). We found that 1 and 2 are mol. catalysts and that O-O bond formation proceeds via oxo-oxo coupling rather than by the water nucleophilic attack (WNA) pathway. In contrast, complex 3 displays negligible catalytic activity. DFT calculations suggested that the anti to syn isomerization of the two high-valent Fe=O moieties in these catalysts takes place via the axial rotation of one Fe=O unit around the Fe-O-Fe center. This is followed by the O-O bond formation via an oxo-oxo coupling pathway at the Fe^IVFe^IV state or via oxo-oxyl coupling pathway at the Fe^IVFe^V state. Importantly, the rigid BPMAN ligand in complex 3 limits the anti to syn isomerization and axial rotation of the Fe=O moiety, which accounts for the negligible catalytic activity.

Angewandte Chemie, International Edition published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C17H16O2, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Vesce, Luigi published the artcileEfficient and stable perovskite large area cells by low-cost fluorene-xantene-based hole transporting layer, Name: Spiro[fluorene-9,9′-xanthene], the publication is Energies (Basel, Switzerland) (2021), 14(19), 6081, database is CAplus.

Among the new generation photovoltaics, perovskite solar cell (PSC) technol. reached top efficiencies in a few years. Currently, the main objective to further develop PSCs is related to the fabrication of stable devices with cost-effective materials and reliable fabrication processes to achieve a possible industrialization pathway. In the n-i-p device configuration, the hole transporting material (HTM) used most is the highly doped organic spiro-fluorene-based material (Spiro-OMeTAD). In addition to the high cost related to its complex synthesis, this material has different issues such as poor photo, thermal and moisture stability. Here, we test on small and large area PSCs a com. available HTM (X55, Dyenamo) with a new core made by low-cost fluorene-xantene units. The one-pot synthesis of this compound reduces 30 times its cost with respect to Spiro-OMeTAD. The optoelectronic performances and properties are characterized through JV measurement, IPCE (incident photon to current efficiency), steady-state photoluminescence and ISOS stability test. SEM (scanning electron microscope) images reveal a uniform and pinhole free coverage of the X55 HTM surface, which reduces the charge recombination losses and improves the device performance relative to Spiro-OMeTAD from 16% to 17%. The ISOS-D-1 stability test on large area cells without any encapsulation reports an efficiency drop of about 15% after 1000 h compared to 30% for the reference case.

Energies (Basel, Switzerland) published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C13H10O2, Name: Spiro[fluorene-9,9′-xanthene].

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ryan, Christopher W. published the artcileA phase I/II dose-escalation study of exisulind and docetaxel in patients with hormone-refractory prostate cancer, Application of Sulindac sulfone, the publication is BJU International (2005), 95(7), 963-968, database is CAplus and MEDLINE.

OBJECTIVE: To determine the safety and efficacy, in a dose-escalation study, of exisulind (an oral sulfone metabolite of sulindac thought to induce apoptosis in malignant cells by inhibiting cGMP-phosphodiesterase) combined with docetaxel in men with hormone-refractory prostate cancer (HRPC), as pre-clin. studies suggested activity against prostate cancer and synergy with cytotoxic agents. PATIENTS AND METHODS: Thirty-four patients with HRPC were treated with oral exisulind twice daily for 21-day cycles and i.v. docetaxel given for 1 h on the first day of each cycle. Three dose levels were assessed, combining exisulind 150 and 250 mg twice daily with docetaxel at 60 or 75 mg/m². Toxicity was then evaluated using standard criteria. RESULTS: The recommended phase II dose was determined to be exisulind 250 mg and docetaxel 60 mg/m², with escalation to 75 mg/m² after cycle 1, as tolerated. The most common grade 3-4 toxicities among all patients were neutropenia (56%), infection (24%) and hyperglycemia (18%). Twelve of 32 evaluable patients (38%, 95% confidence interval, CI, 23-55%) had a decline in PSA by at least half. Only four of 17 evaluable patients (95% CI, 1-47%) treated at the phase II dose level had such a decline in PSA. The median (95% CI) overall survival of all patients was 16 (12.9-19.7) months and median progression-free survival 4.7 (2.7-5.2) months. CONCLUSION: The combination of exisulind and docetaxel was tolerable in patients with HRPC. The PSA response rates do not suggest an improvement over historical data with single-agent docetaxel in this population.

BJU International published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Application of Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sauter, Alexander published the artcileSulindac sulfone induces a decrease of β-catenin in HNSCC, Synthetic Route of 59973-80-7, the publication is Anticancer Research (2010), 30(2), 339-344, database is CAplus.

Background: The most common neoplasm arising in the upper gastrointestinal tract is head and neck squamous cell carcinoma (HNSCC). This is an aggressive epithelial malignancy. Many growth factors and cytokines have been discovered that are responsible for the growth and formation of tumors. Among these factors, β-catenin is considered to be the most important for reducing cell-cell adhesions in malignant tissue. The degradation of β-catenin triggers apoptosis by different routes. Sulindac sulfone has been shown to induce apoptosis in several different tumors. In the present study, we surveyed the concentration of β-catenin in an HNSCC line after incubation with different concentrations of sulindac sulfone. Materials and Methods: Immunohistochem. and Western blot analyses were performed after treatment of the UMSCC 11A cell line with different concentrations of sulindac sulfone (100, 200, 400, 600 and 800 μMol) for 48 h. Results: At 100 μMol of sulindac sulfone, a decrease in β-catenin concentration of 5% was observed; increasing concentrations of sulindac sulfone resulted in >70% reduction in secreted β-catenin. Thus in conclusion, incubation with sulindac sulfone seemed to stop proliferation. With respect to the controls, there was no greater reduction in total protein. Conclusion: In this study, sulindac sulfone reduced levels of secreted β-catenin in the HNSCC cell line UM-SCC 11A after 48 h of incubation. It is presumed that reduction of cell-cell adhesion, which is predominately affected by β-catenin, is an essential step in the progression from localized malignancy to stromal and vascular invasion and ultimately metastatic disease. The reduction in the level of mural expression of β-catenin has been associated with loss of differentiation in laryngeal carcinomas. Thus, prevention of intracellular β-catenin accumulation is regarded as an attractive target for chemopreventive agents.

Anticancer Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Synthetic Route of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem