Month: December 2022

Dogan, Seda published the artcilePhotophysical and photovoltaic characterization of flourene-anthracene-benzothiadiazole based donor-acceptor type copolymers for bulk heterojunction polymer solar cells, Category: naphthyridine, the publication is Journal of Nanoelectronics and Optoelectronics (2019), 14(1), 8-18, database is CAplus.

Photophys. and photovoltaic properties of donor-acceptor type fluorene-anthracene and benzothiadiazole based copolymers were investigated. Bulk heterojunction polymer solar cells were fabricated. The distinction of the two polymers lies in the difference between the donor-acceptor ratios. We have compared their photovoltaic performances and investigated the effect of thickness of blend films on the device performance. The polymer having higher fluorene content exhibited higher photovoltaic performance. We have also observed that one of the polymers depending on the donor-acceptor ratio can act both as a donor and an acceptor in bulk heterojunction polymer solar cells. The solar cells fabricated from thinner blend films showed better photovoltaic performance. It was observed that the thickness slightly affects the morphol. of the blend films.

Journal of Nanoelectronics and Optoelectronics published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Krasovskiy, Arkady published the artcileTransition-metal-free homocoupling of organomagnesium compounds, Name: 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Angewandte Chemie, International Edition (2006), 45(30), 5010-5014, database is CAplus and MEDLINE.

A wide range of functionalized Grignard compounds were coupled by using diphenoquinone I as an electron acceptor. The oxidative dimerization of alkenylmagnesium reagents proceeds with complete retention of the stereochem.

Angewandte Chemie, International Edition published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Name: 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Tiripicchio, Antonio published the artcileComplexes of rhodium(I) with 1,8-naphthyridine and related ligands. Crystal structure of bis(μ-1,8-naphthyridine-N,N’)bis[(η-2,5-norbornadiene)rhodium(I)](Rh-Rh) diperchlorate monohydrate, Computed Properties of 14903-78-7, the publication is Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) (1984), 125-31, database is CAplus.

A series of Rh complexes with 1,8-naphthyridine (L) or its 2-Me (L¹) and 2,7-di-Me analogs was prepared by substitution of the corresponding (diene)Rh complexes. E.g., treating [L²Rh(OCMe₂)_n](ClO₄) (L² = 2,5-norbornadiene) with L in Me₂CO gave the title compound, [(μ-L)₂Rh₂L²₂](ClO₄), isolated as its monohydrate (I). The structure of I was determined by x-ray crystallog. I is binuclear, with 2 L ligands bridging the 2 Rh atoms. Aged samples of the related complexes [L₂Rh₂(CO)₄](ClO₄) and [L¹₂Rh₂(CO)₄](ClO₄) exploded violently during microanal.

Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C6H9N3, Computed Properties of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Patel, Darshna K. published the artcileEnzyme mediated bacterial biotransformation and reduction in toxicity of 1:2 chromium complex AB193 and AB194 dyes, Computed Properties of 116-63-2, the publication is Journal of the Taiwan Institute of Chemical Engineers (2017), 1-9, database is CAplus.

A bacterial consortium was developed and applied for the treatment of 1:2 chromium complex azo dyes. Fed batch process was studied with optimized conditions for the decolorization of AB193 and AB194 up to 1100-1400 mg L^-1 of cumulative dye concentration without further nutrient addition Fed batch adapted consortium showed 39 and 42% enhanced decolorization for AB193 and AB194, resp. as compared to unadapted consortium. After bio-degradation of the dyes, chromium was not detected in the medium supernatant where as chromium was found sorbed on bacterial cell biomass. During the decolorization process laccase, lignin peroxidase, tyrosinase, azoreductase and NADH-DCIP reductase enzymes were found to be induced. HPLC and FTIR anal. data confirmed the biodegradation of both the dyes. Biodegradation pathways were proposed on the basis of H¹ NMR and GC-HRMS anal. along with role of induced enzymic system in the degradation process. 45-66% stimulation in growth was observed for Sorghum bicolor and Cicer aeriatinum when biodegradation products of both the dyes were used. Reduction in toxicity on S. aureus and P. aeruginosa was recorded in the range of 58-100% and 43-100%, resp.

Journal of the Taiwan Institute of Chemical Engineers published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Ge, Yiyue published the artcileAn integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19, Formula: C20H17FO4S, the publication is Signal Transduction and Targeted Therapy (2021), 6(1), 165, database is CAplus and MEDLINE.

The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019 (COVID-19). In this study, we developed an integrative drug repositioning framework, which fully takes advantage of machine learning and statistical anal. approaches to systematically integrate and mine large-scale knowledge graph, literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2. Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1 (PARP1) inhibitor, CVL218, currently in Phase I clin. trial, may be repurposed to treat COVID-19. Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect. In addition, we showed that CVL218 can interact with the nucleocapsid (N) protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathol. induced by SARS-CoV-2 infection.

Signal Transduction and Targeted Therapy published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Newkome, George R. published the artcileFunctionalization of 2-methyl- and 2,7-dimethyl-1,8-naphthyridine, Formula: C10H10N2, the publication is Journal of Organic Chemistry (1990), 55(9), 2838-42, database is CAplus.

2,7-Dimethyl-1,8-naphthyridine (I) was prepared from 2-methyl-1,8-naphthyridine (II) by reaction with 3 equiv of MeLi. Oxidation of I with 8 equiv of N-chlorosuccinimide gave 98% naphthyridine III (R = R¹ = CCl₃) (IV), while oxidation with 4 equiv gave 97% III (R = R¹ = CHCl₂). Hydrolysis of IV with H₃PO₄ followed by esterification gave the diester III (R = R¹ = CO₂Me) (V) in 80% overall yield. Reduction of V with NaBH(OMe)₃ afforded 55% III (R = R¹ = CH₂OH). Similar functionalization of II afforded III (R = H, R¹ = CCl₃) (VI) in 85-94% yield, along with 6-chloro-2-(trichloromethyl)-1,8-naphthyridine. Methanolysis of VI gave 78% III (R = H, R¹ = CO₂Me), which on reduction with NaBH(OMe)₃ afforded 59% III (R = H, R¹ = CH₂OH). Treatment of VI with KOH caused a displacement of the trichloromethyl moiety, generating 1,8-naphthyridin-2-one VII (R¹ = H) as the sole product. Similarly, IV gave VII (R¹ = CCl₃) under mild conditions or a mixture of VII (R¹ = CO₂Et, CCl₃) when refluxed in EtOH.

Journal of Organic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Formula: C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zhou, Qing-cheng published the artcileDesign and synthesis of PPV conjugated light-emitting polymers containing binaphthalene, Related Products of naphthyridine, the publication is Faguang Xuebao (2005), 26(4), 441-447, database is CAplus.

Conjugated polymers as light emitting materials have attracted considerable attention during the past several decades. There is substantial ongoing research towards the design of blue light emitting materials for OLEDs based on conjugated polymers. The conjugation length, steric hindrance within the polymer, must be controlled for such purpose. It is well known that the binaphthyl unit possesses a large dihedral angle ranging from 60° to 120°. Therefore, the conjugation of the binaphthyl-containing polymers can be interrupted by the highly twisted binaphthyl unit. In addition, the highly twisted structure will reduce the intermol. interaction of the polymers. As a result, the binaphthyl-containing polymers will have high quantum efficiency and good solubility Binaphthalene chromophores were introduced into the backbone of conjugated copolymers with different aromatic groups by Wittig or Wittig-Horner reaction, three linear copolymers and a hyperbranched copolymer containing binaphthyl unites were synthesized. All the copolymers were characterized by FT-IR, ¹H NMR. They were readily dissolved in the common solvents such as tetrahydrofuran(THF), dichloromethane, and chloroform. Their photophys. properties have been studied. The results indicated that all copolymers show pure blue light emitting. It is mentionable that the hyperbranched copolymer BN-TPPV shows the highest quantum efficiency (95%) among the four copolymers, which exhibits two emission band peaked at 393 nm and 410 nm in chloroform and one broad emission band peaked at 428 nm in solid film. Cyclic voltammetry was employed to investigated the electrochem. properties of the polymers, their band gaps were ranging from 2.76 eV to 3.05 eV, this result testified that the polymers, BN-PPV, BN-PBPV, BN-TPPV, have the potential to be applied as blue light emitting materials. The results show that it is a practical way to prepare blue light emitting polymers by incorporating binaphthyl into polymer chain.

Faguang Xuebao published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C7H11N, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Baumgartner, Maria T. published the artcileSteric effects in the synthesis of ortho-substituted 1,1′-binaphthalene derivatives by the S_RN1 and the Stille Reaction, COA of Formula: C22H18O2, the publication is ARKIVOC (Gainesville, FL, United States) (2003), 420-433, database is CAplus.

The scope of the S_RN1 mechanism and the Stille reaction to synthesize 1,1′-binaphthalene derivatives was investigated. The best yield of 2′-methoxy-1,1′-binaphthalenyl-2-ol (52%) was obtained in liquid ammonia or DMSO by the S_RN1 irradiated reaction of 1-iodo-2-methoxynaphthalene with the anion of 2-naphthol. A lower yield (40%) of BINOL is obtained in water with 1-iodo-2-hydroxynaphthalene as substrate when the reaction is sonicated before irradiation The Stille reaction between (2-methoxy-1-naphthyl)-trimethylstannane and 1-iodo-2-methoxynaphthalene afforded low yields (15-11%) of the 1,1′-binaphthalene derivative Based on AM1 and B3LYP calculations the yields of the 1,1′-binaphthalene derivatives obtained through the electron transfer S_RN1 reaction can be attributed to kinetic factors of the radical nucleophile coupling step.

ARKIVOC (Gainesville, FL, United States) published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, COA of Formula: C22H18O2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Santos, Fernando published the artcileInteractions of sulindac and its metabolites with phospholipid membranes: An explanation for the peroxidation protective effect of the bioactive metabolite, Synthetic Route of 59973-80-7, the publication is Free Radical Research (2008), 42(7), 639-650, database is CAplus and MEDLINE.

Non-steroidal anti-inflammatory drugs (NSAIDs) treat inflammatory processes by inhibition of cyclooxygenase (COX). However, their action against lipid peroxidation can be an alternative pathway to COX inhibition. Since inflammation and lipid peroxidation are cell-surface phenomena, the effects of NSAIDs on membrane models were investigated. Peroxidation was induced by peroxyl radical (ROO^·) derived from AAPH and assessed in aqueous or lipid media using fluorescence probes with distinct lipophilic properties: fluorescein; HDAF and DPH-PA. The antioxidant effect of Sulindac and its metabolites was tested and related with their membrane interactions. Drug-membrane interactions included the study of: drug location by fluorescence quenching; drug interaction with membrane surface by zeta-potential measurements; and membrane fluidity changes by steady-state anisotropy. Results revealed that the active NSAID (sulindac sulfide) penetrates into the lipid bilayer and protects the membrane against oxy-radicals. The inactive forms (sulindac and sulindac sulfone) present weaker interactions with the membrane and are better radical scavengers in aqueous media.

Free Radical Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Synthetic Route of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem