Month: December 2022

Pinxterhuis, Erik B. published the artcileFast, Efficient and Low E-Factor One-Pot Palladium-Catalyzed Cross-Coupling of (Hetero)Arenes, SDS of cas: 2960-93-2, the publication is Angewandte Chemie, International Edition (2018), 57(30), 9452-9455, database is CAplus and MEDLINE.

The homocoupling of aryl halides and the heterocoupling of aryl halides with either aryl bromides or arenes bearing an ortho-lithiation directing group are presented. The use of a Pd catalyst, in combination with t-BuLi, allows for the rapid and efficient formation of a wide range of polyaromatic compounds in a one pot procedure bypassing the need for the sep. preformation of an organometallic coupling partner. These polyaromatic structures were obtained in high yields, in 10 min at room temperature, with minimal waste generation (E-factors as low as 1.5) and without the need for strict inert conditions, making this process highly efficient and practical in comparison to classical methods. As illustration, several key intermediates of widely used BINOL-derived structures are readily prepared including the highly desired precursor to the chiral TRIP phosphoric acid.

Angewandte Chemie, International Edition published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, SDS of cas: 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Dahal, Gopal P. published the artcileA Fragment Library Screening Approach to Identify Selective Inhibitors against an Essential Fungal Enzyme, Product Details of C10H9NO4S, the publication is SLAS Discovery (2018), 23(6), 520-531, database is CAplus and MEDLINE.

Pathogenic fungi represent a growing threat to human health, with an increase in the frequency of drug-resistant fungal infections. Identifying targets from among the selected metabolic pathways that are unique to microbial species presents an opportunity to develop new antifungal agents against new and untested targets to combat this growth threat. Aspartate semialdehyde dehydrogenase (ASADH) catalyzes a key step in a uniquely microbial amino acid biosynthetic pathway and is essential for microbial viability. This enzyme, purified from four pathogenic fungal organisms (Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Blastomyces dermatitidis), has been screened against fragment libraries to identify initial enzyme inhibitors. The binding of structural analogs of the most promising lead compounds was measured against these fungal ASADHs to establish important structure-activity relationships among these different inhibitor classes. The most potent of these inhibitors have been docked into structures of this fungal enzyme target to identify important structural elements that serve as critical binding determinants. Several inhibitors with low micromolar inhibition constants have been identified that showed selectivity against these related enzymes from different fungal species. Subsequent screening against a library of drugs and drug candidates identified some addnl. inhibitors containing a consistent set of functional groups required for fungal ASADH inhibition. Addnl. elaboration of these core structures will likely lead to more potent and selective inhibitors.

SLAS Discovery published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Product Details of C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Behlen, Michael J. published the artcileC₂-Symmetric dinickel catalysts for enantioselective [4 + 1]-cycloadditions, Safety of 2,7-Dimethyl-1,8-naphthyridine, the publication is Journal of the American Chemical Society (2020), 142(41), 17294-17300, database is CAplus and MEDLINE.

Dinickel naphthyridine-bis(oxazoline) catalysts promote enantioselective intermol. [4 + 1]-cycloadditions of vinylidene equivalent and 1,3-dienes. The products of this reaction are methylenecyclopentenes, and the exocyclic alkene is generally obtained with high Z selectivity. E- and Z-dienes react in a stereoconvergent fashion, providing cycloadducts with the same sense of absolute stereochem. and nearly identical ee values. This feature allows dienes that are com. available as E/Z mixtures to be used as substrates for the cycloaddition A DFT model for the origin of asym. induction is provided.

Journal of the American Chemical Society published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Safety of 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Duncan, Kristal published the artcileNSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo, COA of Formula: C20H17FO4S, the publication is IUBMB Life (2012), 64(7), 636-643, database is CAplus and MEDLINE.

Ovarian cancer (OC) is one of the most lethal gynaecol. cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown that several nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the treatment of OC. Furthermore, we have previously described the mol. mechanisms of NSAIDs’ induction of cancer apoptosis. In this report, we evaluated various structurally distinct NSAIDs for their efficacies in inducing apoptosis in nonproliferating OC cells. Although several NSAIDs-induced apoptosis, Flufenamic Acid, Flurbiprofen, Finasteride, Celocoxib, and Ibuprofen were the most potent NSAIDs inducing apoptosis. A combination of these agents resulted in an enhanced effect. Furthermore, we demonstrate that the combination of Flurbiprofen, which targets nonproliferative cells, and Sulindac Sulfide, that affects proliferative cells, strongly reduced tumor growth when compared with a single agent treatment. Our data strongly support the hypothesis that drug treatment regimens that target nonproliferating and proliferating cells may have significant efficacy against OC. These results also provide a rationale for employing compounds or even chem. modified NSAIDs, which selectively and efficiently induce apoptosis in cells during different stages of the cell cycle, to design more potent anticancer drugs. © 2012 IUBMB IUBMB Life, 2012.

IUBMB Life published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, COA of Formula: C20H17FO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Vintu, M. published the artcileIndolo[3,2-b]carbazole-based poly(arylene ethynylene)s through Sonogashira coupling for optoelectronic and sensing applications, Formula: C18H10, the publication is Journal of Applied Polymer Science (2019), 136(2), n/a, database is CAplus.

Two indolo[3,2-b]carbazole (ICZ)-based polymers were designed and synthesized using Sonogashira cross-coupling based on dibromoindolo[3,2-b]carbazoles and 2,7-diethynylfluorene or 9,10-diethynylanthracene. The 2, 8 positions of the ICZ moiety was used for the bridging of arylene ethynylene structure to form the polymer backbone. The characterization was done by FTIR, ¹H NMR, UV-visible and (UV-visible) fluorescence spectroscopic methods. The polymers, moderately soluble in aprotic and chlorinated solvents, possess thermal stability >300°. The band gap examinations, executed through cyclic voltammetry and complemented by UV-visible studies, indicated their semiconducting nature and the possibility for their use for the fabrication of polymer solar cells and for optical switching applications. The new diethynylindolocarbazole systems act as Broensted acid sensors as well as a Hg²⁺ receptors. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46940.

Journal of Applied Polymer Science published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C8H13BN2O4, Formula: C18H10.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Weissenfels, Manfred published the artcilePhotocatalytic systems. VIII. Preparation of 1,8-naphthyridine aldehydes, Formula: C10H10N2, the publication is Zeitschrift fuer Chemie (1978), 18(1), 20-1, database is CAplus.

Oxidation of methylnaphthyridines I (R = Me, R¹ = H, Me) with SeO₂ gave the corresponding aldehydes I (R = CHO, R¹ = H, CHO), characterized as the oximes, semicarbazones, etc. Benzoin reaction of I (R = CHO, R¹ = H) gave II, which was oxidized by air to III.

Zeitschrift fuer Chemie published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C5H10N2OS, Formula: C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Achilli, Simona published the artcileSteric hindrance in the on-surface synthesis of diethynyl-linked anthracene polymers, Category: naphthyridine, the publication is Physical Chemistry Chemical Physics (2022), 24(22), 13616-13624, database is CAplus and MEDLINE.

Hybrid sp-sp² structures can be efficiently obtained on metal substrates via on-surface synthesis. The choice of both the precursor and the substrate impacts on the effectiveness of the process and the stability of the formed structures. Here we demonstrate that using anthracene-based precursor mols. on Au(111) the formation of polymers hosting sp carbon chains is affected by the steric hindrance between aromatic groups. In particular, by scanning tunneling microscopy experiments and d. functional theory simulations we show that the de-metalation of organometallic structures induces a lateral separation of adjacent polymers that prevents the formation of ordered domains. This study contributes to the understanding of the mechanisms driving the on-surface synthesis processes, a fundamental step toward the realization of novel carbon-based nanostructures with perspective applications in nanocatalysis, photoconversion, and nano-electronics.

Physical Chemistry Chemical Physics published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C18H10, Category: naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Takeuchi, Motoharu published the artcile[2.2]Naphthalenophanes from intermolecular [2 + 2] photocycloadditions of divinylnaphthalenes, Computed Properties of 152873-79-5, the publication is Journal of Organic Chemistry (1993), 58(26), 7388-92, database is CAplus.

Syn-[2.2]naphthalenophanes, e.g., I, were obtained exclusively in reasonable yields from the intermol. [2 + 2] photocycloadditions of divinylnaphthalenes. The position of the vinyl group and the type of vinyl substituent affected the isomer ratio of the products. The structures of naphthalenophanes were elucidated by ¹H-NMR spectroscopy including COSY and NOESY experiments Among the divinylnaphthalenes examined, 1,4-, 1,5-, and 1,6-ones did not give the desired naphthalenophanes. By taking advantage of the effect of the substituents on the photoreaction, the authors could obtain [2.2](1,5)naphthalenophane derivatives from 1,5-bis(β-carboethoxyethenyl)naphthalene and 1,5-bis(β-phenylethenyl)naphthalene, but the authors could not obtain the 1,4-isomers, probably because they are highly strained. Although a mixture of two different divinylnaphthalenes was irradiated, only homoadducts were obtained; no cross adducts were detected.

Journal of Organic Chemistry published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C38H74Cl2N2O4, Computed Properties of 152873-79-5.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Barluenga, Jose published the artcileDirect intramolecular arylation of aldehydes promoted by reaction with IPy₂BF₄/HBF₄: synthesis of benzocyclic ketones, Related Products of naphthyridine, the publication is Angewandte Chemie, International Edition (2006), 45(19), 3140-3143, database is CAplus and MEDLINE.

Aldehydes acylated arenes upon treatment at low temperature with IPy₂BF₄ and HBF₄. This reaction was exploited in a novel intramol. approach to the preparation of benzocyclic ketones, e.g., I. A plausible mechanistic rational was also given.

Angewandte Chemie, International Edition published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C12H6F6O6S2, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Fernandes, Eduarda published the artcileThe metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species, Recommanded Product: Sulindac sulfone, the publication is Free Radical Biology & Medicine (2003), 35(9), 1008-1017, database is CAplus and MEDLINE.

Sulindac is a sulfoxide prodrug that, in vivo, is converted to the metabolites sulindac sulfide and sulindac sulfone. It is therapeutically used as an anti-inflammatory and analgesic in the symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. In addition to its anti-inflammatory properties, sulindac and its metabolites have been shown to have an important role in the prevention of colonic carcinogenesis. Although the inhibition of prostaglandin synthesis constitutes the primary mechanism of action of sulindac, it is well known that reactive oxygen species (ROS) and reactive nitrogen species (RNS) are implicated in the pathophysiol. of inflammation and cancer. Thus, the aim of this study was to evaluate the scavenging activity of sulindac and its sulfone and sulfide metabolites for an array of ROS (HO^•, O₂^•-, and HOCl) and RNS (^•NO and ONOO^–) using in vitro systems. The results we obtained demonstrate that the metabolism of sulindac increases its scavenging activity for all RNS and ROS studied, notably with regard to the scavenging of HOCl. These effects may strongly contribute to the anti-inflammatory and anticarcinogenic efficacy that has been shown for sulindac.

Free Radical Biology & Medicine published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Recommanded Product: Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem