Iwuagwu, Christiana et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Related Products of 5912-35-6

Design and synthesis of a novel series of 4-heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR was written by Iwuagwu, Christiana;King, Dalton;McDonald, Ivar M.;Cook, James;Zusi, F. Christopher;Hill, Matthew D.;Mate, Robert A.;Fang, Haiquan;Knox, Ronald;Gallagher, Lizbeth;Post-Munson Amy Easton, Debra;Miller, Regina;Benitex, Yulia;Siuciak, Judy;Lodge, Nicholas;Zaczek, Robert;Morgan, Daniel;Bristow, Linda;Macor, John E.;Olson, Richard E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Related Products of 5912-35-6 This article mentions the following:

Quinuclidine-containing spirooxazolines, as described in the previous report in this series, were demonstrated to have utility as α7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists. In this work, the SAR of this chemotype was expanded to include an array of diazine heterocyclic substitutions. Many of the heterocyclic analogs were potent partial agonists of the α7 receptor, selective against other nicotinic receptors and the serotininergic 5HT3A receptor. (1’S,3’R,4’S)-N-(6-phenylpyrimidin-4-yl)-4H-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octan]-2-amine, a potent and selective α7 nAChR partial agonist, was demonstrated to improve cognition in the mouse novel object recognition (NOR) model of episodic memory. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Related Products of 5912-35-6).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Related Products of 5912-35-6

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem