Cyclization of dinitriles by sodium alkoxides. New synthesis of naphthyridines was written by Alhaique, F.;Riccieri, F. M.;Santucci, E.. And the article was included in Tetrahedron Letters in 1975.Safety of 6-Amino-8-bromo-1,7-naphthyridine This article mentions the following:
Dicyanopyridine derivatives with alcs. and Na cyclized to give aminoalkoxynaphthyridines. E.g., I and II with EtOH and Na gave 70% III and 72% IV, resp. The yield decreased with increasing size of alc. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Safety of 6-Amino-8-bromo-1,7-naphthyridine).
6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves. The corresponding thiazolonaphthyridine is obtained from a similar reaction using 2-aminoethanethiol and Dowex basic anion-exchange resin.Safety of 6-Amino-8-bromo-1,7-naphthyridine
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem