Sauter, Alexander published the artcileSulindac sulfone induces a decrease of β-catenin in HNSCC, Synthetic Route of 59973-80-7, the publication is Anticancer Research (2010), 30(2), 339-344, database is CAplus.
Background: The most common neoplasm arising in the upper gastrointestinal tract is head and neck squamous cell carcinoma (HNSCC). This is an aggressive epithelial malignancy. Many growth factors and cytokines have been discovered that are responsible for the growth and formation of tumors. Among these factors, β-catenin is considered to be the most important for reducing cell-cell adhesions in malignant tissue. The degradation of β-catenin triggers apoptosis by different routes. Sulindac sulfone has been shown to induce apoptosis in several different tumors. In the present study, we surveyed the concentration of β-catenin in an HNSCC line after incubation with different concentrations of sulindac sulfone. Materials and Methods: Immunohistochem. and Western blot analyses were performed after treatment of the UMSCC 11A cell line with different concentrations of sulindac sulfone (100, 200, 400, 600 and 800 μMol) for 48 h. Results: At 100 μMol of sulindac sulfone, a decrease in β-catenin concentration of 5% was observed; increasing concentrations of sulindac sulfone resulted in >70% reduction in secreted β-catenin. Thus in conclusion, incubation with sulindac sulfone seemed to stop proliferation. With respect to the controls, there was no greater reduction in total protein. Conclusion: In this study, sulindac sulfone reduced levels of secreted β-catenin in the HNSCC cell line UM-SCC 11A after 48 h of incubation. It is presumed that reduction of cell-cell adhesion, which is predominately affected by β-catenin, is an essential step in the progression from localized malignancy to stromal and vascular invasion and ultimately metastatic disease. The reduction in the level of mural expression of β-catenin has been associated with loss of differentiation in laryngeal carcinomas. Thus, prevention of intracellular β-catenin accumulation is regarded as an attractive target for chemopreventive agents.
Anticancer Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Synthetic Route of 59973-80-7.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem