Huang, Wei-Hua published the artcileSimultaneous determination of sulindac and its metabolites sulindac sulfide and sulindac sulfone in human plasma by a sensitive UPLC-PDA method for a pharmacokinetic study, Synthetic Route of 59973-80-7, the publication is Analytical Methods (2014), 6(13), 4679-4685, database is CAplus.
A sensitive, rapid and reliable ultra-performance liquid chromatog. (UPLC) with Photo-Diode Array (PDA) detection method was developed for simultaneous determination of sulindac and its metabolites sulindac sulfide and sulindac sulfone in human plasma. The analytes were extracted by dichloromethane from human plasma using a liquid-liquid extraction method. The chromatog. separation was performed on a Waters Acquity UPLC with a Waters Acquity UPLC BEH C18 column (2.1 × 50 mm i.d., 1.7 μm) within 5 min. The mobile phase used for gradient elution consisted of ammonium formate buffer (20 mM) containing 1% acetic acid and acetonitrile. The flow rate was maintained at 0.4 mL min-1. The monitor wavelength was set at 328 nm for PDA detection. All calibration curves of the analytes showed good linearity within the test ranges. The validated method was successfully applied to a pharmacokinetic study of sulindac, sulindac sulfide and sulindac sulfone in 15 healthy Chinese male subjects with oral administration of sulindac tablets.
Analytical Methods published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Synthetic Route of 59973-80-7.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem