Zhu, Junchen’s team published research in Journal of Separation Science in 43 | CAS: 2960-93-2

Zhu, Junchen published the artcileA novel C₂ symmetric chiral stationary phase with N-[(4-Methylphenyl)sulfonyl]-L-leucine as chiral side chains, Computed Properties of 2960-93-2, the publication is Journal of Separation Science (2020), 43(12), 2338-2348, database is CAplus and MEDLINE.

In this study, a series of chiral stationary phases based on N-[(4-methylphenyl)sulfonyl]-L-leucine amide, whose enantiorecognition property has never been studied, were synthesized. Their enantioseparation abilities were chromatog. evaluated by 67 enantiomers. The chiral stationary phase derived from N-[(4-methylphenyl)sulfonyl]-L-leucine showed much better enantioselectivities than that based on N-(4-methylbenzoyl)-L-leucine amide. The construction of C₂ sym. chiral structure greatly improved the enantiorecognition performance of the stationary phase. The C₂ sym. chiral stationary phase exhibited superior enantioresolns. to other chiral stationary phases for most of the chiral analytes, especially for the chiral analytes with C₂ sym. structures. By comparing the enantioseparations of the enantiomers with similar structures, the importance of hydrogen bond interaction, π-π interaction, and steric hindrance on enantiorecognition was elucidated. The enantiorecognition mechanism of trans-N,N’-(1,2-diphenyl-1,2-ethanediyl)bis-acetamide, which had an excellent separation factor on the C₂ sym. chiral stationary phase, was investigated by ¹H-NMR spectroscopy and 2D ¹H-¹H nuclear overhauser enhancement spectroscopy.

Journal of Separation Science published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C14H10N2O, Computed Properties of 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem