Zheng, Xuehua published the artcileThe molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase, Safety of Sulindac sulfone, the publication is FEBS Letters (2012), 586(1), 55-59, database is CAplus and MEDLINE.
Sulindac (SLD) exhibits both the highest inhibitory activity towards human aldose reductase (AR) among popular non-steroidal anti-inflammatory drugs and clear beneficial clin. effects on Type 2 diabetes. However, the mol. basis for these properties is unclear. Here, we report that SLD and its pharmacol. active/inactive metabolites, SLD sulfide and SLD sulfone, are equally effective as un-competitive inhibitors of AR in vitro. Crystallog. anal. reveals that π-π stacking favored by the distinct scaffold of SLDs is pivotal to their high AR inhibitory activities. These results also suggest that SLD sulfone could be a potent lead compound for AR inhibition in vivo.
FEBS Letters published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C13H24INO4, Safety of Sulindac sulfone.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem