Zheng, Xuehua’s team published research in FEBS Letters in 586 | CAS: 59973-80-7

FEBS Letters published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C13H24INO4, Safety of Sulindac sulfone.

Zheng, Xuehua published the artcileThe molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase, Safety of Sulindac sulfone, the publication is FEBS Letters (2012), 586(1), 55-59, database is CAplus and MEDLINE.

Sulindac (SLD) exhibits both the highest inhibitory activity towards human aldose reductase (AR) among popular non-steroidal anti-inflammatory drugs and clear beneficial clin. effects on Type 2 diabetes. However, the mol. basis for these properties is unclear. Here, we report that SLD and its pharmacol. active/inactive metabolites, SLD sulfide and SLD sulfone, are equally effective as un-competitive inhibitors of AR in vitro. Crystallog. anal. reveals that π-π stacking favored by the distinct scaffold of SLDs is pivotal to their high AR inhibitory activities. These results also suggest that SLD sulfone could be a potent lead compound for AR inhibition in vivo.

FEBS Letters published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C13H24INO4, Safety of Sulindac sulfone.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem