Dai, Zhi published the artcileSolution-phase synthesis and evaluation of tetraproline chiral stationary phases, Application of 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Chirality (2012), 24(4), 329-338, database is CAplus and MEDLINE.
Fmoc-Pro-Pro-Pro-Pro-OH and Fmoc-Pro-Pro-Pro-Pro-NMe(CH2)3CO2H were prepared on multigramm scale by a solution-phase synthetic route; the two peptides were attached to (methylamino)propylated silica gel, deprotected, and acylated with pivaloyl chloride to provide silica gel-bound Me3CCO-Pro-Pro-Pro-Pro-N(Me)CH2CH2CH2R (R = silica) and Me3CCO-Pro-Pro-Pro-Pro-NMe(CH2)3CONHCH2CH2CH2R (R = silica) as chiral stationary phases for the separation of a variety of organic analytes. The resolution of analytes with the two chiral stationary phases prepared from tetraproline peptides were compared to the resolution of analytes by tetraproline synthesized on (methylamino)propylated silica gel; all three silica-bound tetraproline peptides had similar chromatog. performance for resolving the 53 model analytes tested. This suggests that the solution-phase synthesis of oligoprolines, which allows for the specific benefits of good batch reproducibility, selector homogeneity, and possibly low cost, is a feasible alternative to the solid-phase synthesis of oligoproline CSPs. © 2012 Wiley Periodicals, Inc.
Chirality published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Application of 2,2′-Dimethoxy-1,1′-binaphthalene.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem