New synthesis of 1,7-naphthyridine was written by Tan, Rosita;Taurins, Alfred. And the article was included in Tetrahedron Letters in 1966.Related Products of 5912-35-6 This article mentions the following:
NH4OH (60 ml., 28%) and 22.4 g. 2,3-NCC5H3NCH2CO2Et stirred 5 hrs. at 10° and the mixture kept 2 days at 0° the crystalline product chromatographed and crystallized from tetrahydrofuran gave 2,3-NCC5-H3NCH2CONH2, m. 145.5-6.0°. The acetamide (4.4 g.) treated at -10 to +5° with POCl3-C5H5N, the mixture kept 2.5 hrs. at 65°, and extracted with CH2Cl2 gave 2,3-NCC5H3NCH2CN, m. 64.0-5.5° (C6H6-C6H14). The nitrile treated with anhydrous HBr in Et2O and poured into aqueous NaHCO3 yielded 72% cyclized product, 6-amino-8-bromo-1,7-naphthyridine (I), m. 181° (decomposition) (C6H6-CHCl3), hydrogenated in alc. KOH over 10% Pd-C to yield 81% 6-amino-1,7-naphthyridine (II), m. 174.0-4.5°. II (1.5 g.) in 20 ml. dioxane refluxed 1 hr. at 110° with 10 ml. N2H4.H2O gave 64.5% 6,8-dihydrazino-1,7-naphthyridine (III), m. 147.5-9.5° (corrected). III in 30% AcOH poured slowly into hot aqueous CuSO4 and the mixture boiled 15 min., made alk. with 20% NaOH and extracted continuously with Et2O, the product purified by chromatography and crystallized from petroleum ether yielded 18% pure 1,7-naphthyridine, m. 61-2° (corrected), [monopicrate m. 196.5-7.5° (corrected)]. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Related Products of 5912-35-6).
6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Related Products of 5912-35-6
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem