Tan, Rosita et al. published their research in Tetrahedron Letters in 1966 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Related Products of 5912-35-6

New synthesis of 1,7-naphthyridine was written by Tan, Rosita;Taurins, Alfred. And the article was included in Tetrahedron Letters in 1966.Related Products of 5912-35-6 This article mentions the following:

NH4OH (60 ml., 28%) and 22.4 g. 2,3-NCC5H3NCH2CO2Et stirred 5 hrs. at 10° and the mixture kept 2 days at 0° the crystalline product chromatographed and crystallized from tetrahydrofuran gave 2,3-NCC5-H3NCH2CONH2, m. 145.5-6.0°. The acetamide (4.4 g.) treated at -10 to +5° with POCl3-C5H5N, the mixture kept 2.5 hrs. at 65°, and extracted with CH2Cl2 gave 2,3-NCC5H3NCH2CN, m. 64.0-5.5° (C6H6-C6H14). The nitrile treated with anhydrous HBr in Et2O and poured into aqueous NaHCO3 yielded 72% cyclized product, 6-amino-8-bromo-1,7-naphthyridine (I), m. 181° (decomposition) (C6H6-CHCl3), hydrogenated in alc. KOH over 10% Pd-C to yield 81% 6-amino-1,7-naphthyridine (II), m. 174.0-4.5°. II (1.5 g.) in 20 ml. dioxane refluxed 1 hr. at 110° with 10 ml. N2H4.H2O gave 64.5% 6,8-dihydrazino-1,7-naphthyridine (III), m. 147.5-9.5° (corrected). III in 30% AcOH poured slowly into hot aqueous CuSO4 and the mixture boiled 15 min., made alk. with 20% NaOH and extracted continuously with Et2O, the product purified by chromatography and crystallized from petroleum ether yielded 18% pure 1,7-naphthyridine, m. 61-2° (corrected), [monopicrate m. 196.5-7.5° (corrected)]. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Related Products of 5912-35-6).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Related Products of 5912-35-6

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Hersperger, Rene et al. published their research in Journal of Medicinal Chemistry in 2000 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological activities. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Recommanded Product: 5912-35-6

Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of 6,8-Disubstituted 1,7-Naphthyridines: A Novel Class of Potent and Selective Phosphodiesterase Type 4D Inhibitors was written by Hersperger, Rene;Bray-French, Katharine;Mazzoni, Lazzaro;Mueller, Thomas. And the article was included in Journal of Medicinal Chemistry in 2000.Recommanded Product: 5912-35-6 This article mentions the following:

Recently, four subtypes of the human phosphodiesterase type 4 (PDE4A-D) enzyme have been described. So far, only very few PDE4 subtype-selective inhibitors are known. Herein, we describe the synthesis of 6,8-disubstituted 1,7-naphthyridines and their characterization as potent and selective inhibitors of PDE4D which suppress the oxidative burst in human eosinophils with IC50 values as low as 0.7 nM. SAR development and the extended use of palladium-catalyzed cross-coupling reactions led to a compound which inhibited human PDE4D with an IC50 value of 1 nM. Thus, the compound was 55, 175, and 1000 times more potent in inhibiting PDE4D over PDE4B, PDE4A, and PDE4C. In a Brown Norway rat model of allergic asthma, the compound when given by the oral route (1 mg/kg) reduced by more than 50% the influx of eosinophils, T-cells, and neutrophils into bronchoalveolar lavage fluid (BALF) samples obtained from antigen-challenged animals. Thus, PDE4D-selective inhibitors of the 1,7-naphthyridine class have the potential as an oral therapy for treating asthma. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Recommanded Product: 5912-35-6).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological activities. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Recommanded Product: 5912-35-6

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Nishimura, Nobuko et al. published their research in Journal of Medicinal Chemistry in 2011 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves.Recommanded Product: 6-Amino-8-bromo-1,7-naphthyridine

Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure-Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives was written by Nishimura, Nobuko;Siegmund, Aaron;Liu, Longbin;Yang, Kevin;Bryan, Marian C.;Andrews, Kristin L.;Bo, Yunxin;Booker, Shon K.;Caenepeel, Sean;Freeman, Daniel;Liao, Hongyu;McCarter, John;Mullady, Erin L.;San Miguel, Tisha;Subramanian, Raju;Tamayo, Nuria;Wang, Ling;Whittington, Douglas A.;Zalameda, Leeanne;Zhang, Nancy;Hughes, Paul E.;Norman, Mark H.. And the article was included in Journal of Medicinal Chemistry in 2011.Recommanded Product: 6-Amino-8-bromo-1,7-naphthyridine This article mentions the following:

The phosphoinositide 3-kinase (PI3K) family catalyzes the ATP-dependent phosphorylation of the 3′-hydroxyl group of phosphatidylinositols and plays an important role in cell growth and survival. There is abundant evidence demonstrating that PI3K signaling is dysregulated in many human cancers, suggesting that therapeutics targeting the PI3K pathway may have utility for the treatment of cancer. Our efforts to identify potent, efficacious, and orally available PI3K/mammalian target of rapamycin (mTOR) dual inhibitors resulted in the discovery of a series of substituted quinolines and quinoxalines derivatives In this report, we describe the structure-activity relationships, selectivity, and pharmacokinetic data of this series and illustrate the in vivo pharmacodynamic and efficacy data for a representative compound In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Recommanded Product: 6-Amino-8-bromo-1,7-naphthyridine).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves.Recommanded Product: 6-Amino-8-bromo-1,7-naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Day, Jonathan P. et al. published their research in Journal of Medicinal Chemistry in 2011 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Halogen atoms attached to the naphthyridine moiety can be easily replaced by other nucleophiles such as alkoxides and amines.Category: naphthyridine

Elucidation of a Structural Basis for the Inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4 (PDE4A4) was written by Day, Jonathan P.;Lindsay, Barbara;Riddell, Tracy;Jiang, Zhong;Allcock, Robert W.;Abraham, Achamma;Sookup, Sebastian;Christian, Frank;Bogum, Jana;Martin, Elisabeth K.;Rae, Robert L.;Anthony, Diana;Rosair, Georgina M.;Houslay, Daniel M.;Huston, Elaine;Baillie, George S.;Klussmann, Enno;Houslay, Miles D.;Adams, David R.. And the article was included in Journal of Medicinal Chemistry in 2011.Category: naphthyridine This article mentions the following:

A survey of PDE4 inhibitors reveals that some compounds trigger intracellular aggregation of PDE4A4 into accretion foci through association with the ubiquitin-binding scaffold protein p62 (SQSTM1). We show that this effect is driven by inhibitor occupancy of the catalytic pocket and stabilization of a “capped state” in which a sequence within the enzyme’s upstream conserved region 2 (UCR2) module folds across the catalytic pocket. Only certain inhibitors cause PDE4A4 foci formation, and the structural features responsible for driving the process are defined. Switching to the UCR2-capped state induces conformational transition in the enzyme’s regulatory N-terminal portion, facilitating protein association events responsible for reversible aggregate assembly. PDE4-selective inhibitors able to trigger relocalization of PDE4A4 into foci can therefore be expected to exert actions on cells that extend beyond simple inhibition of PDE4 catalytic activity and that may arise from reconfiguring the enzyme’s protein association partnerships. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Category: naphthyridine).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Halogen atoms attached to the naphthyridine moiety can be easily replaced by other nucleophiles such as alkoxides and amines.Category: naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Hersperger, Rene et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2002 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6, 1,7, 1,8, 2,6, or 2,7 positions. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications.Formula: C8H6BrN3

Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor was written by Hersperger, Rene;Dawson, Janet;Mueller, Thomas. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Formula: C8H6BrN3 This article mentions the following:

The synthesis of a 6,8-disubstituted 1,7-naphthyridine and its characterization as a potent and selective phosphodiesterase type 4D inhibitor (IC50=1.5 nM) are described. The title compound, i.e., 4-[8-(2,1,3-benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acid and 4-[8-(2,1,3-benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acid salt with 1-deoxy-1-(methylamino)-D-glucitol. The compound inhibited TNFα-release from human peripheral blood mononuclear cells and was orally active in a model of adjuvant-induced arthritis in rats. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Formula: C8H6BrN3).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6, 1,7, 1,8, 2,6, or 2,7 positions. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications.Formula: C8H6BrN3

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Iwuagwu, Christiana et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Related Products of 5912-35-6

Design and synthesis of a novel series of 4-heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR was written by Iwuagwu, Christiana;King, Dalton;McDonald, Ivar M.;Cook, James;Zusi, F. Christopher;Hill, Matthew D.;Mate, Robert A.;Fang, Haiquan;Knox, Ronald;Gallagher, Lizbeth;Post-Munson Amy Easton, Debra;Miller, Regina;Benitex, Yulia;Siuciak, Judy;Lodge, Nicholas;Zaczek, Robert;Morgan, Daniel;Bristow, Linda;Macor, John E.;Olson, Richard E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Related Products of 5912-35-6 This article mentions the following:

Quinuclidine-containing spirooxazolines, as described in the previous report in this series, were demonstrated to have utility as α7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists. In this work, the SAR of this chemotype was expanded to include an array of diazine heterocyclic substitutions. Many of the heterocyclic analogs were potent partial agonists of the α7 receptor, selective against other nicotinic receptors and the serotininergic 5HT3A receptor. (1’S,3’R,4’S)-N-(6-phenylpyrimidin-4-yl)-4H-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octan]-2-amine, a potent and selective α7 nAChR partial agonist, was demonstrated to improve cognition in the mouse novel object recognition (NOR) model of episodic memory. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Related Products of 5912-35-6).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Related Products of 5912-35-6

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Alhaique, F. et al. published their research in Tetrahedron Letters in 1975 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves. The corresponding thiazolonaphthyridine is obtained from a similar reaction using 2-aminoethanethiol and Dowex basic anion-exchange resin.Safety of 6-Amino-8-bromo-1,7-naphthyridine

Cyclization of dinitriles by sodium alkoxides. New synthesis of naphthyridines was written by Alhaique, F.;Riccieri, F. M.;Santucci, E.. And the article was included in Tetrahedron Letters in 1975.Safety of 6-Amino-8-bromo-1,7-naphthyridine This article mentions the following:

Dicyanopyridine derivatives with alcs. and Na cyclized to give aminoalkoxynaphthyridines. E.g., I and II with EtOH and Na gave 70% III and 72% IV, resp. The yield decreased with increasing size of alc. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Safety of 6-Amino-8-bromo-1,7-naphthyridine).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves. The corresponding thiazolonaphthyridine is obtained from a similar reaction using 2-aminoethanethiol and Dowex basic anion-exchange resin.Safety of 6-Amino-8-bromo-1,7-naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Press, Neil J. et al. published their research in Journal of Medicinal Chemistry in 2012 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Halogen atoms attached to the naphthyridine moiety can be easily replaced by other nucleophiles such as alkoxides and amines.Recommanded Product: 5912-35-6

Solubility-Driven Optimization of Phosphodiesterase-4 Inhibitors Leading to a Clinical Candidate was written by Press, Neil J.;Taylor, Roger J.;Fullerton, Joseph D.;Tranter, Pamela;McCarthy, Clive;Keller, Thomas H.;Arnold, Nicola;Beer, David;Brown, Lyndon;Cheung, Robert;Christie, Julie;Denholm, Alastair;Haberthuer, Sandra;Hatto, Julia D. I.;Keenan, Mark;Mercer, Mark K.;Oakman, Helen;Sahri, Helene;Tuffnell, Andrew R.;Tweed, Morris;Tyler, John W.;Wagner, Trixie;Fozard, John R.;Trifilieff, Alexandre. And the article was included in Journal of Medicinal Chemistry in 2012.Recommanded Product: 5912-35-6 This article mentions the following:

The solubility-driven optimization of a series of 1,7-naphthyridine phosphodiesterase-4 inhibitors is described. Directed structural changes resulted in increased aqueous solubility, enabling superior pharmacokinetic properties with retention of PDE4 inhibition. A range of potent and orally bioavailable compounds with good in vivo efficacy in animal models of inflammation and reduced emetic potential compared to previously described drugs were synthesized. Compound 2d (I) was taken forward as a clin. candidate for the treatment of COPD. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Recommanded Product: 5912-35-6).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Halogen atoms attached to the naphthyridine moiety can be easily replaced by other nucleophiles such as alkoxides and amines.Recommanded Product: 5912-35-6

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Srivastava, K. P. et al. published their research in International Journal of ChemTech Research in 2014 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological activities. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Name: 6-Amino-8-bromo-1,7-naphthyridine

Efficient and eco-friendly synthesis of 1,7-naphthyridines was written by Srivastava, K. P.;Indusingh;Kumari, Anupma. And the article was included in International Journal of ChemTech Research in 2014.Name: 6-Amino-8-bromo-1,7-naphthyridine This article mentions the following:

A microwave-promoted new easy, efficient, clean and environmentally benign method for the synthesis of 1,7-naphthyridine and its derivatives from 2-cyano-3-pyridylacetonitrile has been developed. The desired products were isolated in excellent yields and high purity under eco-friendly conditions. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Name: 6-Amino-8-bromo-1,7-naphthyridine).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological activities. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Name: 6-Amino-8-bromo-1,7-naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Srivastava, K. P. et al. published their research in International Journal of Chemical and Physical Sciences in 2014 | CAS: 5912-35-6

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridine ring system, being very π-deficient, is highly vulnerable towards nucleophilic attack, and consequently there has been extensive investigation of reactions involving nitrogen nucleophiles. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Name: 6-Amino-8-bromo-1,7-naphthyridine

Efficient and eco-friendly synthesis of 1,7-naphthyridines was written by Srivastava, K. P.;Indu, Singh;Anupma, Kumari. And the article was included in International Journal of Chemical and Physical Sciences in 2014.Name: 6-Amino-8-bromo-1,7-naphthyridine This article mentions the following:

A microwave-promoted new easy, efficient, clean and environmentally benign method for the synthesis of 1,7-naphthyridine and its derivatives I [R1 = NH2; R2 = H, Br] from 2-cyano-3-pyridylacetonitrile has been developed. The desired products were isolated in excellent yields and high purity under eco-friendly conditions. In the experiment, the researchers used many compounds, for example, 6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6Name: 6-Amino-8-bromo-1,7-naphthyridine).

6-Amino-8-bromo-1,7-naphthyridine (cas: 5912-35-6) belongs to naphthyridine derivatives. The naphthyridine ring system, being very π-deficient, is highly vulnerable towards nucleophilic attack, and consequently there has been extensive investigation of reactions involving nitrogen nucleophiles. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Name: 6-Amino-8-bromo-1,7-naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem