Month: November 2022

Roy, Biswajit published the artcileGround-State Proton-Transfer (GSPT)-Assisted Enhanced Two-Photon Uncaging from a Binol-based AIE-Fluorogenic Phototrigger, Application of 2,2′-Dimethoxy-1,1′-binaphthalene, the publication is Organic Letters (2021), 23(6), 2308-2313, database is CAplus and MEDLINE.

We demonstrated for the first time without any chem. modification the two-photon absorption (TPA) cross-section can be enhanced and red-shifted to the near-IR (NIR) region by the ground-state proton-transfer (GSPT) process. Using GSPT, we developed a simple binol-based aggregation-induced emission (AIE)-fluorogenic phototrigger having a large two-photon uncaging cross-section in the “phototherapeutic window”. As a proof of concept, we showed our phototrigger for the release of two different anticancer drugs in the NIR region.

Organic Letters published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C22H18O2, Application of 2,2′-Dimethoxy-1,1′-binaphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wang, Sha-Sha published the artcileVariable segment roles: modulation of the packing modes, nanocrystal morphologies and optical emissions, Computed Properties of 159-62-6, the publication is Nanoscale (2018), 10(28), 13310-13314, database is CAplus and MEDLINE.

A review. Three isomers were prepared by covalently grafting carbazole (Cz) onto spiro[fluorene-9,9′-xanthene] (SFX) at different positions. Due to the complicated and variable roles of mol. segments, an evolution of the corresponding mol. packing mode was realized, accompanied by the change of nanocrystal morphol. and photoluminescence properties.

Nanoscale published new progress about 159-62-6. 159-62-6 belongs to naphthyridine, auxiliary class Other Aromatic Heterocyclic,Spiro, name is Spiro[fluorene-9,9′-xanthene], and the molecular formula is C24H29N5O3, Computed Properties of 159-62-6.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Hindenberg, Philip published the artcileEn Route Towards the Control of Luminescent, Optically-Active 3D Architectures, Name: 1,5-NAphthalenebis(trifluoromethanesulfonate), the publication is Angewandte Chemie, International Edition (2021), 60(2), 766-773, database is CAplus and MEDLINE.

π-Extended systems are key components for the development of future organic electronic technologies. While conceiving mols. with improved properties is fundamental for the evolution of materials science, keeping control over the 3D arrangement of mols. represents an ever-expanding challenge. Herein, a synthetic protocol to replace carbon atoms of π-systems by dissym. phosphorus atoms is reported; in particular, it allowed for conceiving new fused phosphapyrene derivatives with improved properties. The presence of dissym. phosphorus atoms precluded the formation of excimers. X-ray diffraction revealed that, meanwhile, strong intermol. interactions are taking place in the solid state. The phosphapyrenes photoluminesce in the visible region with high quantum yields; importantly, they are CD-active. In addition, the unique non-planar features of phosphorus atoms allowed for the control of the 3D arrangement of mols., rendering lemniscate-like structures. Based on our discoveries, we envisage the possibility to construct higher-order, chiral 3D architectures from larger phosphorus-containing π-systems.

Angewandte Chemie, International Edition published new progress about 152873-79-5. 152873-79-5 belongs to naphthyridine, auxiliary class Trifluoromethyl,Sulfonate,Benzene, name is 1,5-NAphthalenebis(trifluoromethanesulfonate), and the molecular formula is C12H6F6O6S2, Name: 1,5-NAphthalenebis(trifluoromethanesulfonate).

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Parte, Satish published the artcileBiodegradation of sulfonated aromatic amine by Pseudomonas desmolyticum NCIM 2112, Related Products of naphthyridine, the publication is Journal of Chemical and Pharmaceutical Research (2013), 5(4), 335-339, database is CAplus.

Environmental pollutions caused by the release of wide range of compounds from various industries such as paper pulp and textiles have a serious effect on ecosystem and human health. Sulfonated azo dyes represent a large class of dyes used in textile industries. The precursors of these dyes are sulfonated aromatic amines. Release of such toxic compounds in the environment cause toxic effects on soil fertility and aquatic ecosystem. Limited attention has been paid towards the fate of sulfonated aromatic amines and substituted sulfonated aromatic amines in the environment previously. The present research work describes biodegradation of azo dye precursor 1-amino 2-naphthol 4-sulfonic acid by Pseudomonas desmolyticum NCIM 2112 which was studied by FTIR and GCMS anal. The resulting metabolites of biodegradation include propylmethane thiosulfonate and aminobenzene and they were found to be nontoxic in the environment.

Journal of Chemical and Pharmaceutical Research published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Dutta Gupta, Sayan published the artcile2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: Rational identification of a new anticancer lead, Computed Properties of 116-63-2, the publication is Bioorganic Chemistry (2015), 97-105, database is CAplus and MEDLINE.

Hsp90 is a mol. chaperone that heals diverse array of biomols. ranging from multiple oncogenic proteins to the ones responsible for development of resistance to chemotherapeutic agents. Moreover they are over-expressed in cancer cells as a complex with co-chaperones and under-expressed in normal cells as a single free entity. Hence inhibitors of Hsp90 will be more effective and selective in destroying cancer cells with min. chances of acquiring resistance to them. In continuation of our goal to rationally develop effective small mol. azomethines against Hsp90, we designed few more compounds belonging to the class of 2,4-dihydroxy benzaldehyde derived imines (1-13) with our validated docking protocol. The mols. exhibiting good docking score were synthesized and their structures were confirmed by IR, ¹H NMR and mass spectral anal. Subsequently, they were evaluated for their potential to suppress Hsp90 ATPase activity by Malachite green assay. The antiproliferative effect of the mols. were examined on PC3 prostate cancer cell lines by adopting 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay methodol. Finally, schiff base 13 emerged as the lead mol. for future design and development of Hsp90 inhibitors as anticancer agents.

Bioorganic Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Hendricker, David G. published the artcileNaphthyridine complexes of Group VIb metal carbonyls, SDS of cas: 14903-78-7, the publication is Inorganic Chemistry (1969), 8(3), 685-7, database is CAplus.

M(CO)6 (M = Cr, Mo, W) and 2,7-dimethyl-1,8-naphthyridine (L) were refluxed in octane to afford M(CO)4L which were characterized by ir spectra. Also prepared were M(CO)4L’ (L’ = 2,9-dimethyl-1,10-phenanthroline). The ir spectra of M(CO)4L and M(CO)4L’ in the CO stretching region are very similar in number, position, and intensity of absorptions of the analogous complexes of 2,2′-bipyridine and 1,10-phenanthroline. The π-bonding ability of L and L’ is discussed on the basis of the force constants Preliminary investigations of substitution reactions of M(CO)4L with various monodentate ligands indicate that the reaction rate is similar to that reported for complexes containing 5-member chelate rings and thus suggests similar labilizing properties.

Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, SDS of cas: 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Narayanan, Bhagavathi A. published the artcileExisulind in combination with Celecoxib modulates epidermal growth factor receptor, cyclooxygenase-2, and cyclin D1 against prostate carcinogenesis: in vivo evidence, Computed Properties of 59973-80-7, the publication is Clinical Cancer Research (2007), 13(19), 5965-5973, database is CAplus and MEDLINE.

Nonsteroidal anti-inflammatory drugs mediate anticancer effects by modulating cyclooxygenase-2 (COX-2)-dependent and/or COX-2-independent mechanism(s); however, the toxicity issue is a concern with single agents at higher doses. In this study, we determined the combined effect of celecoxib, a COX-2 inhibitor, along with exisulind (sulindac sulfone/Aptosyn) at low doses in prostate cancer. We used a sequential regimen of N-methyl-N-nitrosourea + testosterone to induce prostate cancer in Wistar-Unilever rats. Following carcinogen treatment, celecoxib and exisulind individually and their combination at low doses were given in NIH-07 diet for 52 wk. We determined the incidence of prostatic intraepithelial neoplasia, adenocarcinomas, rate of tumor cell proliferation, and apoptosis. Immunohistochem. and Western blot anal. were done to determine COX-2, epidermal growth factor receptor (EGFR), Akt, androgen receptor, and cyclin D1 expression. Serum prostaglandin E₂ and tumor necrosis factor-α levels were determined using enzyme immunoassay/ELISA assays. The rats that received celecoxib in combination with exisulind at low doses showed a significant decrease in prostatic intraepithelial neoplasia and adenocarcinomas as well as an enhanced rate of apoptosis. An overall decrease in COX-2, EGFR, Akt, androgen receptor, and cyclin D1 expression was found associated with tumor growth inhibition. Reduced serum levels of COX-2 protein, prostaglandin E₂, and tumor necrosis factor-α indicated anti-inflammatory effects. A strong inhibition of total and phosphorylated form of EGFR (Tyr⁹⁹² and Tyr⁸⁴⁵) and Akt (Ser⁴⁷³) was significant in rats given with these agents in combination. In this study, we show for the first time that the combination of celecoxib with exisulind at low doses could prevent prostate carcinogenesis by altering key mol. events.

Clinical Cancer Research published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Computed Properties of 59973-80-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Masoud, Mamdouh S. published the artcileSolvatochromic responses and pH effects on the electronic spectra of some azo derivatives of 1-amino-2-hydroxy-4-naphthalenesulfonic acid, Formula: C10H9NO4S, the publication is Journal of the Iranian Chemical Society (2016), 13(5), 931-943, database is CAplus.

Synthesis and characterization of five arylazo derivatives of 1-amino-2-hydroxy-4-naphthalenesulfonic acid (H2L1) are reported. The UV/Vis absorption spectra of the parent compound (H2L1) and its arylazo derivatives (H2L2-H4L6) have been measured at room temperature in seven solvents of different polarities and with variable parameters. The electronic transitions were analyzed using SPSS program, linear regression technique and Kamlet-Taft’s equation to permit a good understanding of solvent-induced spectral shifts. The electronic absorption spectra of the prepared compounds containing different substituents were studied in aqueous solutions at different pH values. The pK values of the investigated compounds were evaluated spectrophotometrically. The prevailing acid species present at any pH range are judged from the constructed distribution diagrams.

Journal of the Iranian Chemical Society published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Formula: C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sivakumar, Kullampalayam Krishnasamy published the artcileConventional and microwave assisted synthesis of pyrazolone Mannich bases possessing anti-inflammatory, analgesic, ulcerogenic effect and antimicrobial properties, SDS of cas: 116-63-2, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(13), 2940-2944, database is CAplus and MEDLINE.

In the present study, an efficient synthesis of some Mannich base of 5-methyl-2-[(2-oxo-2H-chromen-3-yl)carbonyl]-2,4-dihydro-3H-pyrazol-3-one was carried out by using conventional and non-conventional (microwave) techniques. Microwave assisted reactions showed that require shorter reaction time and good yield. The newly synthesized compounds were screened for their anti-inflammatory, analgesic activity, antioxidant, and antibacterial effects were compared with standard drug. Among the compounds studied, one compound showing nearly equipotent anti-inflammatory and analgesic activity than the standard drug (indomethacin), along with min. ulcerogenic index. Two compounds showing 1.06 times more active than ciprofloxacin against tested Gram-neg. bacteria.

Bioorganic & Medicinal Chemistry Letters published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C9H5ClO4S, SDS of cas: 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Yin, Jingjun published the artcileA Highly Active Suzuki Catalyst for the Synthesis of Sterically Hindered Biaryls: Novel Ligand Coordination, Computed Properties of 2960-93-2, the publication is Journal of the American Chemical Society (2002), 124(7), 1162-1163, database is CAplus and MEDLINE.

A catalyst system for the preparation of biaryls containing four ortho substituents via Suzuki coupling is described. The combination of a catalytic quantity of Pd₂(dba)₃ with either an electron-rich biarylphosphine or DPEPhos is effective using a wide range of substrates. The X-ray crystal structure of (dba)Pd[2-(9-phenanthryl)phenyl-dicyclohexylphosphine], in which the Pd is coordinated to the 9,10-double bond of the phenanthryl group, is also reported.

Journal of the American Chemical Society published new progress about 2960-93-2. 2960-93-2 belongs to naphthyridine, auxiliary class Naphthalene,Ether,Other MOF ligands,Organic ligands for MOF materials, name is 2,2′-Dimethoxy-1,1′-binaphthalene, and the molecular formula is C20H19NO4, Computed Properties of 2960-93-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem