Sivakumar, Kullampalayam Krishnasamy published the artcileConventional and microwave assisted synthesis of pyrazolone Mannich bases possessing anti-inflammatory, analgesic, ulcerogenic effect and antimicrobial properties, SDS of cas: 116-63-2, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(13), 2940-2944, database is CAplus and MEDLINE.
In the present study, an efficient synthesis of some Mannich base of 5-methyl-2-[(2-oxo-2H-chromen-3-yl)carbonyl]-2,4-dihydro-3H-pyrazol-3-one was carried out by using conventional and non-conventional (microwave) techniques. Microwave assisted reactions showed that require shorter reaction time and good yield. The newly synthesized compounds were screened for their anti-inflammatory, analgesic activity, antioxidant, and antibacterial effects were compared with standard drug. Among the compounds studied, one compound showing nearly equipotent anti-inflammatory and analgesic activity than the standard drug (indomethacin), along with min. ulcerogenic index. Two compounds showing 1.06 times more active than ciprofloxacin against tested Gram-neg. bacteria.
Bioorganic & Medicinal Chemistry Letters published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C9H5ClO4S, SDS of cas: 116-63-2.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem