Romeiro, Nelilma C. published the artcileNSAIDs revisited: Putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARγ), Category: naphthyridine, the publication is European Journal of Medicinal Chemistry (2008), 43(9), 1918-1925, database is CAplus and MEDLINE.
This paper describes mol. docking studies of a series of classical NSAIDs with PPARγ receptor, which has been pointed as a new target for the design of anticancer and antiinflammatory drugs, and has been found to be responsible for some of the already established pharmacol. effects observed for marketed drugs. The results show the mol. basis of PPARγ activation by non-selective COX inhibitors.
European Journal of Medicinal Chemistry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Category: naphthyridine.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem