Gasparini, Laura published the artcileModulation of β-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures, Related Products of naphthyridine, the publication is Journal of Neurochemistry (2004), 88(2), 337-348, database is CAplus and MEDLINE.
Alzheimer disease (AD) is characterized by cerebral deposits of β-amyloid (Aβ) peptides, which are surrounded by neuroinflammatory cells. Epidemiol. studies have shown that prolonged use of non-steroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing AD. In addition, biol. data indicate that certain NSAIDs specifically lower Aβ42 levels in cultures of peripheral cells independently of cyclooxygenase (COX) activity and reduce cerebral Aβ levels in AD transgenic mice. Whether other NSAIDs, including COX-selective compounds, modulate Aβ levels in neuronal cells remains unexploited. Here, we investigated the effects of compounds from every chem. class of NSAIDs on Aβ40 and Aβ42 secretion using both Neuro-2a cells and rat primary cortical neurons. Among non-selective NSAIDs, flurbiprofen and sulindac sulfide concentration-dependently reduced the secretion not only of Aβ42 but also of Aβ40. Surprisingly, both COX-2 (celecoxib; s.c.-125) or COX-1 (s.c.-560) selective compounds significantly increased Aβ42 secretion, and either did not alter (s.c.-560; s.c.-125) or reduced (celecoxib) Aβ40 levels. The levels of βAPP C-terminal fragments and Notch cleavage were not altered by any of the NSAIDs, indicating that γ-secretase activity was not overall changed by these drugs. The present findings show that only a few non-selective NSAIDs possess Aβ-lowering properties and therefore have a profile potentially relevant to their clin. use in AD.
Journal of Neurochemistry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Related Products of naphthyridine.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem