Singh, Jatinder published the artcileCoordination-Driven Self-Assembly of Triazole-Based Apoptosis-Inducible Metallomacrocycles, Synthetic Route of 18512-55-5, the publication is ACS Omega (2019), 4(6), 10810-10817, database is CAplus and MEDLINE.
Ru(II)-metallomacrocycles containing 4-pyridyl-1,2,3-triazole moiety were realized by coordination-driven self-assembly. All new compounds were characterized by ESI-MS, elemental anal., 1H and 13C NMR spectroscopies. The mol. structure of metallomacrocycle 8 was established by single-crystal x-ray crystallog. The anticancer activities of metallomacrocycles 5–8 were evaluated by cytotoxicity, cell cycle anal., and related protein expression. Metallomacrocycle 7 showed greatest cytotoxicity in HepG2 human hepatocellular carcinoma cells. Apoptotic HepG2 cells were analyzed when metallomacrocycle 7 was treated. The results suggest that metallomacrocycle 7 induce liver cancer cell death by increasing apoptosis and cell cycle arrest and that it has potential use as an agent for the treatment of human hepatocellular carcinoma.
ACS Omega published new progress about 18512-55-5. 18512-55-5 belongs to naphthyridine, auxiliary class Alkynyl,Anthracene, name is 9,10-Diethynylanthracene, and the molecular formula is C6H16OSi, Synthetic Route of 18512-55-5.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem