Stock, Nicholas published the artcileThe geminal dimethyl analogue of Flurbiprofen as a novel Aβ42 inhibitor and potential Alzheimer’s disease modifying agent, Recommanded Product: Sulindac sulfone, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(8), 2219-2223, database is CAplus and MEDLINE.
The subtle modification of a selection of Aβ42 inhibiting non-steroidal anti-inflammatory drugs (NSAIDs), through synthesis of the geminal di-Me analogs, was anticipated to ablate their cyclooxygenase activity while maintaining Aβ42 inhibition. Methylflurbiprofen I exhibited similar in vitro Aβ42 inhibition to its parent NSAID Flurbiprofen and was further evaluated in the Tg2576 mouse model of Alzheimer’s disease and an animal model of gastro-intestinal (GI) impairment, but proved unviable for further clin. development.
Bioorganic & Medicinal Chemistry Letters published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C16H10O5, Recommanded Product: Sulindac sulfone.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem