Sinibaldi, Victoria J. published the artcilePhase II evaluation of docetaxel plus exisulind in patients with androgen independent prostate carcinoma, Quality Control of 59973-80-7, the publication is American Journal of Clinical Oncology (2006), 29(4), 395-398, database is CAplus and MEDLINE.
Objectives: In this phase II study, the combination of docetaxel and exisulind (a GMP phosphodiesterase inhibitor) was given to patients with metastatic androgen independent prostate cancer (AIPC) to establish efficacy, assess toxicity, and determine pharmacokinetics of docetaxel administered alone and in combination with exisulind. Methods: Fourteen patients with metastatic AIPC were registered to receive weekly docetaxel for 4 wk, followed by 2 wk of rest; repeated up to a maximum of 6 cycles. Exisulind 250 mg was given orally twice a day starting on day 8 of the study and taken continuously. Results: All patients were evaluable for toxicity, response and survival. Grade 3 reversible toxicities included: fatigue, nausea, diarrhea, abdominal pain, rash, syncope, pulmonary edema, deep vein thrombosis, congestive heart failure, and elevations in transaminases, requiring therapy delays and/or dose reductions, or removal from therapy. Only 3 out of 14 patients (21.4%) had a 50% decline in prostate specific antigen (PSA) level that lasted â? wk; 1 out of 14 patients (7%) had a lymph node response. Median survival was 17.28 mo. Docetaxel pharmacokinetics for 11 patients demonstrated mean ± SD clearance values that were similar during week 1 and week 3 when exisulind had been added. Conclusions: Overall, our trial indicated that the toxicity profile and efficacy of this regimen is unlikely to be substantially better than single agent docetaxel.
American Journal of Clinical Oncology published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C10H10O2, Quality Control of 59973-80-7.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem