Nortcliffe, Andrew published the artcileSynthesis and biological evaluation of nitric oxide-donating analogues of sulindac for prostate cancer treatment, Safety of Sulindac sulfone, the publication is Bioorganic & Medicinal Chemistry (2014), 22(2), 756-761, database is CAplus and MEDLINE.
A series of analogs of the non-steroidal anti-inflammatory drug (NSAID) sulindac were synthesized tethered to nitric oxide (NO) donating functional groups. Sulindac shows antiproliferative effects against immortal PC3 cell lines. It was previously demonstrated that the effect can be enhanced when tethered to NO releasing groups such as nitrate esters, furoxans and sydnonimines. To explore this approach further, a number of sulindac-NO analogs were prepared and they were evaluated as NO-releasing cytotoxic agents against prostate cancer (PCa) cell lines. Compounds (I) and (II) exhibited significant cytotoxic with IC50 values of 6.1±4.1 and 12.1±3.2 μM, resp., coupled with observed nitric oxide release.
Bioorganic & Medicinal Chemistry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Safety of Sulindac sulfone.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem