Costa, David published the artcileSinglet oxygen scavenging activity of non-steroidal anti-inflammatory drugs, Product Details of C20H17FO4S, the publication is Redox Report (2008), 13(4), 153-160, database is CAplus and MEDLINE.
It has long been known that singlet oxygen (1O2) is generated during inflammatory processes. Once formed in substantial amounts, 1O2 may have an important role in mediating the destruction of infectious agents during host defense. On the other hand, 1O2 is capable of damaging almost all biol. mols. and is particularly genotoxic, which gives a special relevance to the scavenging of this ROS throughout anti-inflammatory treatments. Considering that the use of non-steroidal anti-inflammatory drugs (NSAIDs) constitutes a first approach in the treatment of persistent inflammatory processes (due to their ability to inhibit cyclooxygenase), a putative scavenging activity of NSAIDs for 1O2 would also represent a significant component of their therapeutic effect. The aim of the present study was to evaluate the scavenging activity for 1O2 by several chem. families of NSAIDs. The results suggested that the pyrazole derivatives (dipyrone and aminopyrine) are, by far, the most potent scavengers of 1O2 (much more potent compared to the other tested NSAIDs), displaying IC50-values in the low micromolar range. There was a lack of activity for most of the arylpropionic acid derivatives tested, with only naproxen and indoprofen displaying residual activities, as for the oxazole derivative, oxaprozin. On the other hand, the pyrrole derivatives (tolmetin and ketorolac), the indolacetic acid derivatives (indomethacin, and etodolac), as well as sulindac and its metabolites (sulindac sulfide and sulindac sulfone) displayed scavenging activity in the high micromolar range. Thus, the scavenging effect observed for dipyrone and aminopyrine will almost certainly contribute to their healing effect in the treatment of prolonged or chronic inflammation, while that of the other studied NSAIDs may have a lower contribution, though these assumptions still require further in vivo validation.
Redox Report published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Product Details of C20H17FO4S.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem