Ziegler, Dorothee S. published the artcileDirected Zincation or Magnesiation of the 2-Pyridone and 2,7-Naphthyridone Scaffold Using TMP Bases, SDS of cas: 67988-50-5, the main research area is zincation magnesiation pyridone naphthyridone methoxyethoxymethyl tetramethylpiperidyl base electrophile.
A regioselective zincation of the 2-pyridone and 2,7-naphthyridone scaffolds has been developed. Zincations of the methoxyethoxymethyl (MEM)-protected compounds using TMP2Zn·2MgCl2·2LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) followed by trapping with electrophiles provided functionalized 2-pyridones, e.g. I, and 2,7-naphthyridones, e.g. II. I/Mg exchange of iodinated 2-pyridone and 2,7-naphthyridone using i-PrMgCl·LiCl afforded magnesiated intermediates that reacted with electrophiles. A second magnesiation of the 2-pyridone scaffold was achieved by using TMPMgCl·LiCl. Addnl., CoCl2-catalyzed cross-couplings of the 1-chloro-2,7-naphthyridines with arylzinc halides is reported.
Organic Letters published new progress about Electrophiles. 67988-50-5 belongs to class naphthyridine, name is 2,7-Naphthyridin-1(2H)-one, and the molecular formula is C8H6N2O, SDS of cas: 67988-50-5.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem