Zhang, Ao’s team published research in Journal of Combinatorial Chemistry in 2007-12-31 | CAS: 67988-50-5

Journal of Combinatorial Chemistry published new progress about Halogenation, regioselective. 67988-50-5 belongs to class naphthyridine, name is 2,7-Naphthyridin-1(2H)-one, and the molecular formula is C8H6N2O, Product Details of C8H6N2O.

Zhang, Ao published the artcileConvenient Synthesis of 2,7-Naphthyridine Lophocladines A and B and their Analogues, Product Details of C8H6N2O, the main research area is lophocladine A B preparation analog; regioselective bromination iodination naphthyridine lophocladine A B preparation; Suzuki lophocladine A B preparation; Stille lophocladine A B preparation; Sonogashira lophocladine A B preparation.

The authors developed a convenient and flexible synthetic route to lophocladines A and B, I and II, resp., as well as their C-4 substituted analogs through a regioselective bromination/iodination of 2,7-naphthyridines followed by a Suzuki, Stille, or Sonogashira reaction. This method is useful for generating a 2,7-naphthyridine library (25 members) with a variant C-4 substituent, including differently substituted aryl, heteroaryl, as well as vinyl, alkyl, and substituted or nonsubstituted acetylenyl groups.

Journal of Combinatorial Chemistry published new progress about Halogenation, regioselective. 67988-50-5 belongs to class naphthyridine, name is 2,7-Naphthyridin-1(2H)-one, and the molecular formula is C8H6N2O, Product Details of C8H6N2O.

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem