Tasker, Nikhil R. published the artcileIn-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors, Formula: C8H6N2O, the main research area is iminothienopyridinedione preparation photooxygenation PTP4A3 phosphatase inhibitor SAR continuous flow.
A continuous flow photooxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones to produce 7-iminothieno[3,2-c]pyridine-4,6(5H,7H)-diones has been developed, utilizing ambient air as the sole reactant. N-H Imines are formed as the major products, and excellent functional group tolerance and conversion on gram-scale without the need for chromatog. purification allow for facile late-stage diversification of the aminothienopyridinone scaffold. Several analogs exhibit potent in vitro inhibition of the cancer-associated protein tyrosine phosphatase PTP4A3, and the SAR supports an exploratory docking model.
Organic & Biomolecular Chemistry published new progress about Antitumor agents. 67988-50-5 belongs to class naphthyridine, name is 2,7-Naphthyridin-1(2H)-one, and the molecular formula is C8H6N2O, Formula: C8H6N2O.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem