Baldwin, J. J. published the artcileA novel naphthyridinone synthesis via enamine cyclization, Name: 2,7-Naphthyridin-1(2H)-one, the main research area is naphthyridinol; cyanomethylpyridine cyclocondensation DMF; methylcyanopyridine cyclocondensation DMF; pyridinecarbonitrile methyl DMF cyclocondensation.
I, II, and III are prepared by the reaction of Me2NCH(OMe)2 with vicinal-substituted methylcyanopyridines, e.g., 4-methyl-3-cyanopyridine. The initial condensation is followed by ring closure of the intermediate enamines IV with HBr/AcOH. The method is especially useful for I and II, which previously had been prepared by cumbersome and low-yielding procedures.
Journal of Organic Chemistry published new progress about Cyclization. 67988-50-5 belongs to class naphthyridine, name is 2,7-Naphthyridin-1(2H)-one, and the molecular formula is C8H6N2O, Name: 2,7-Naphthyridin-1(2H)-one.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem