On May 20, 2010, Shipps, Gerald W., Jr.; Cheng, Cliff C.; Achab, Abdelghani Abe; Yao, Zhiping; Whitehurst, Charles E.; Zhang, Mingxuan; Yang, Xianshu; Herr, Robert Jason; Zych, Andrew John; Roy, Sudipta; Yang, Jinhai published a patent.Electric Literature of 445490-78-8 The title of the patent was Preparation of benzyltetrahydronaphthyridinylethylurea derivatives and analogs for use as HIV blockers. And the patent contained the following:
Title compounds I [L = (un)substituted urea, isothiourea, sulfamide, etc.; R1 = (un)substituted tetrahydronaphthalene, tetrahydronaphthyridine, dihydrobenzothio pyran; each R2 independently = H, (un)substituted alkyl, or cycloalkyl; each R3 independently = H, (un)substituted alkyl, cycloalkyl, or aryl; R4 = (un)substituted aryl, cycloalkyl, or heteroaryl ring containing 1 to 3 heteroatoms selected from O, S, or N; m = 1 to 3; n = 0 to 2], and their pharmaceutically acceptable salts, are prepared and disclosed as HIV blockers. Thus, e.g., II was prepared by coupling of 3,4-dichlorobenzyl isocyanate with 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanamine hydrochloride. Select I were evaluated in HIV CXCR4 affinity assays, e.g., II demonstrated an IC50 value of 2.4 μM. The experimental process involved the reaction of tert-Butyl 7-(2-hydroxyethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate(cas: 445490-78-8).Electric Literature of 445490-78-8
The Article related to naphthyridinylethylurea benzyltetrahydro derivative preparation hiv blocker, benzyltetrahydronaphthyridinylethylurea analog preparation hiv blocker, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 445490-78-8
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem