On November 7, 2002, Sanchez, Juan Jose Marugan; Marder, Victor J.; U’prichard, David C. published a patent.Quality Control of tert-Butyl 7-(2-hydroxyethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate The title of the patent was Substituted benzofurans and benzothiophenes of use as integrin antagonists. And the patent contained the following:
Title compounds I [Y = O, S; X = O, S, CH2, NH; W = N heterocyclic, amino; Z = CR5R6(CH2)i(CR7R8)k(CH2)jCO2R9; R1-R4 = H, alkyl, haloalkyl, aryl, aralkyl; R5-R8 = H, OH, (un)substituted alkyl, alkoxy, cycloalkyl, aryl, heterocyclic; R5R7 = alkylene; R9 = H, alkyl, haloalkyl, aryl, aralkyl, aminoalkyl, alkoxyalkoxyalkyl, alkoxycarbonyloxyethyl; R10-R13 = H, (un)substituted alkyl, aryl; R10R11 = alkylene; i, j, m, n = 0-4; k = 0, 1] were prepared The compounds may be used in the treatment of pathol. conditions mediated by αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. Thus, the benzothiophene II was prepared from tert.-Bu 7-ethoxycarbonylmethyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylate and Et 3-(6-hydroxybenzo[b]thiophen-3-yl)propionate and had IC50 for inhibition of αvβ5-vitronectin in vitro of 8 nM. The experimental process involved the reaction of tert-Butyl 7-(2-hydroxyethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate(cas: 445490-78-8).Quality Control of tert-Butyl 7-(2-hydroxyethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
The Article related to benzothiophenepropionate preparation vitronectin inhibitor, benzofuranpropionate preparation vitronectin inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of tert-Butyl 7-(2-hydroxyethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem