On February 29, 2000, Nishijima, Kazumi; Nishida, Hidemitsu; Yamashita, Yoshiaki; Ito, Manabu; Onuki, Yoshiaki; Mizota, Masahiro; Miyano, Sotaro published an article.Electric Literature of 76629-10-2 The title of the article was Synthesis and diuretic activity of bicyclic fused heterocycles containing oxime-O-sulfonic acid moiety. And the article contained the following:
In order to investigate the origin of the loop-type diuretic activity of M17055, several variants were designed and synthesized by modifying the quinolinone skeleton, and their diuretic activities were compared with the lead M17055 and furosemide in dogs. It was found that the neg. charge distribution pattern afforded by the dispositional arrangement of the 4-oxime-O-sulfonic acid and 1-N-acyl carbonyl moiety attached to the tetrahydropyridine ring system is inevitable for the development of the activity, which strongly supports the previously proposed model for the active site of the Na+-K+-2Cl- cotransporter. The experimental process involved the reaction of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one(cas: 76629-10-2).Electric Literature of 76629-10-2
The Article related to oxime sulfonate heterocycle preparation diuretic structure, Pharmacology: Structure-Activity and other aspects.Electric Literature of 76629-10-2
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem