On March 7, 2002, Ish, Kumar Khanna; Yi, Yu; Balekudru, Devadas; Hwang-Fun, Lu; Nizal, S. Chandrakumar published a patent.Product Details of 445490-78-8 The title of the patent was Compounds containing a pyridinylaminopropoxybicyclic ring system useful as αvβ3 antagonists. And the patent contained the following:
Title compounds were prepared for use as selective inhibitors or antagonists of the αvβ3 and/or αvβ5 integrin. Thus, the benzoxazepine I was prepared by treating 4-benzyloxysalicylaldehyde with BrCMe2CO2CH2Ph and H2NCH2CO2CMe3, debenzylating, cyclizing, reaction with 2-(3-hydroxypropylamino)pyridine 1-oxide, reduction of the N-oxide, and ester hydrolysis. The compounds showed activity in several vitronectin receptor assays. The experimental process involved the reaction of tert-Butyl 7-(2-hydroxyethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate(cas: 445490-78-8).Product Details of 445490-78-8
The Article related to pyridinylaminopropoxy bicyclic compound preparation vitronectin receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Product Details of 445490-78-8
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem