On May 14, 2015, Inukai, Takayuki; Takeuchi, Jun; Yasuhiro, Tomoko; Wolf, Mark Allan; Pawal, Vijay Dattaram; Chakrabarti, Anjan; Chittimalla, Santhosh Kumar published a patent.HPLC of Formula: 869640-41-5 The title of the patent was Pyrrolopyrimidine derivative and its use for pharmaceutical composition for prevention and/or treatment of Axl-related disease. And the patent contained the following:
The compound represented by general formula I [R1 = (un)substituted C1-8 alkyl, (un)substituted C3-7 carbocycle, 4- to 7-membered heterocycle; R2 = (un)substituted C1-8 alkyl, (un)substituted C2-8 alkenyl, (un)substituted C2-8 alkynyl, OH, (un)substituted C3-7 carbocycle, (un)substituted 4- to 7-membered heterocycle, halo, etc.; R3 = C1-4 (halo)alkyl, halo, OH, C1-4 (halo)alkoxy; R4 = H, (un)substituted C1-8 alkyl, (un)substituted C3-10 carbocycle, (un)substituted 4- to 10-membered heterocycle; R5 = H, C1-4 (halo)alkyl, halo; ring1 = 5- to 7-membered cyclic group; m, n = 0-3] has strong Axl inhibition activity by means of a pyridone ring structure being introduced into a pyrrolopyrimidine skeleton, and so the result can serve as a treatment agent for Axl-related diseases, for example cancers such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glial tumors, renal disease, immune system disorders, and cardiovascular disease. Thus, N-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-pyridinyl]-2′,5′-dioxo-1′-phenyl-2′,5′,6′,8′-tetrahydro-1’H-spiro(cyclopropane-1,7′-quinoline)-3′-carboxamide (preparation given) inhibited Axl with IC50 of 0.0097 μmol. The experimental process involved the reaction of 7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one(cas: 869640-41-5).HPLC of Formula: 869640-41-5
The Article related to pyrrolopyrimidine preparation pharmaceutical axl inhibitor disease therapy anticancer, immune system cardiovascular disease treatment axl inhibitor pyrrolopyrimidine preparation and other aspects.HPLC of Formula: 869640-41-5
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem