On February 7, 2019, Huang, Peter Qinhua; Boren, Brant Clayton; Bunker, Kevin Duane; Liu, Hui; Paliwal, Sunil published a patent.Application of 869640-41-5 The title of the patent was Preparation of pyrazolopyrimidinones and salts thereof as WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases. And the patent contained the following:
The invention relates to prepn of pyrazolopyrimidinones and salts thereof as WEE1 kinase inhibitors. The example compound I was prepared accordingby a procedure (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). The compounds of the invention, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer. The experimental process involved the reaction of 7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one(cas: 869640-41-5).Application of 869640-41-5
The Article related to pyrazolopyrimidinone preparation wee1 kinase inhibitor antitumor antiproliferative, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 869640-41-5
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem